Haploinsufficiency by minute MutL homolog 1 promoter DNA methylation may represent unique phenotypes of microsatellite instability-gastric carcinogenesis

Promoter DNA methylation of MutL homolog 1 (MLH1) is considered to play a causative role in microsatellite instability (MSI) carcinogenesis in primary gastric cancer, and a high MSI status is associated with treatment sensitivity to human cancers. Nevertheless, clinicopathological analysis is defect...

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Detalles Bibliográficos
Autores principales: Harada, Hiroki, Nie, Yusuke, Araki, Ippeita, Soeno, Takafumi, Chuman, Motohiro, Washio, Marie, Sakuraya, Mikiko, Ushiku, Hideki, Niihara, Masahiro, Hosoda, Kei, Kumamoto, Yusuke, Naitoh, Takeshi, Sangai, Takafumi, Hiki, Naoki, Yamashita, Keishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694418/
https://www.ncbi.nlm.nih.gov/pubmed/34936649
http://dx.doi.org/10.1371/journal.pone.0260303

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