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Two methods for the preparation of sitagliptin phosphate via chemical resolution and asymmetric hydrogenation

Two effective processes have been developed for the preparation of sitagliptin phosphate. The approach of chemical resolution obtained R-sitagliptin in five steps from commercially available starting materials using the inexpensive NaBH(4) to reduce the enamine and then using (−)-di-p-toluoyl-l-tart...

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Detalles Bibliográficos
Autores principales:	Ye, Fei, Zhang, Zhifeng, Zhao, Wenxia, Ding, Jianhai, Wang, Yali, Dang, Xueyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694546/ https://www.ncbi.nlm.nih.gov/pubmed/35424414 http://dx.doi.org/10.1039/d0ra10273c

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