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Platelet-rich plasma for the treatment of lichen sclerosus
AIM: Evaluate the clinical effectiveness of platelet-rich plasma as a treatment for lichen sclerosus. METHODS: A systematic review was performed. The electronic databases PubMed, Ovid MEDLINE(®), Web of Science, Cochrane, clinicaltrials.gov were used to identify case studies, case series, prospectiv...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694569/ https://www.ncbi.nlm.nih.gov/pubmed/34950752 http://dx.doi.org/10.20517/2347-9264.2021.86 |
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author | Villalpando, Beija K. Wyles, Saranya P. Schaefer, Lauren A. Bodiford, Katherine J. Bruce, Alison J. |
author_facet | Villalpando, Beija K. Wyles, Saranya P. Schaefer, Lauren A. Bodiford, Katherine J. Bruce, Alison J. |
author_sort | Villalpando, Beija K. |
collection | PubMed |
description | AIM: Evaluate the clinical effectiveness of platelet-rich plasma as a treatment for lichen sclerosus. METHODS: A systematic review was performed. The electronic databases PubMed, Ovid MEDLINE(®), Web of Science, Cochrane, clinicaltrials.gov were used to identify case studies, case series, prospective uncontrolled, and randomized controlled studies published between 1946 and April 21, 2021. Six prospective uncontrolled studies, one randomized double-blind prospective study, and one case report were included. RESULTS: Platelet-rich plasma treatment was subjectively reported to improve quality of life, but objective measures demonstrating treatment efficacy were not observed. In addition, platelet-rich plasma preparation and administration between studies lacked standardization. CONCLUSION: Platelet-rich plasma may be used for symptomatic adjuvant treatment of lichen sclerosus, though additional double-blind controlled studies with standardized platelet-rich plasma protocols are needed to better characterize the efficacy of platelet-rich plasma. |
format | Online Article Text |
id | pubmed-8694569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-86945692021-12-22 Platelet-rich plasma for the treatment of lichen sclerosus Villalpando, Beija K. Wyles, Saranya P. Schaefer, Lauren A. Bodiford, Katherine J. Bruce, Alison J. Plast Aesthet Res Article AIM: Evaluate the clinical effectiveness of platelet-rich plasma as a treatment for lichen sclerosus. METHODS: A systematic review was performed. The electronic databases PubMed, Ovid MEDLINE(®), Web of Science, Cochrane, clinicaltrials.gov were used to identify case studies, case series, prospective uncontrolled, and randomized controlled studies published between 1946 and April 21, 2021. Six prospective uncontrolled studies, one randomized double-blind prospective study, and one case report were included. RESULTS: Platelet-rich plasma treatment was subjectively reported to improve quality of life, but objective measures demonstrating treatment efficacy were not observed. In addition, platelet-rich plasma preparation and administration between studies lacked standardization. CONCLUSION: Platelet-rich plasma may be used for symptomatic adjuvant treatment of lichen sclerosus, though additional double-blind controlled studies with standardized platelet-rich plasma protocols are needed to better characterize the efficacy of platelet-rich plasma. 2021-12-05 2021 /pmc/articles/PMC8694569/ /pubmed/34950752 http://dx.doi.org/10.20517/2347-9264.2021.86 Text en https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Villalpando, Beija K. Wyles, Saranya P. Schaefer, Lauren A. Bodiford, Katherine J. Bruce, Alison J. Platelet-rich plasma for the treatment of lichen sclerosus |
title | Platelet-rich plasma for the treatment of lichen sclerosus |
title_full | Platelet-rich plasma for the treatment of lichen sclerosus |
title_fullStr | Platelet-rich plasma for the treatment of lichen sclerosus |
title_full_unstemmed | Platelet-rich plasma for the treatment of lichen sclerosus |
title_short | Platelet-rich plasma for the treatment of lichen sclerosus |
title_sort | platelet-rich plasma for the treatment of lichen sclerosus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694569/ https://www.ncbi.nlm.nih.gov/pubmed/34950752 http://dx.doi.org/10.20517/2347-9264.2021.86 |
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