Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

Heparan sulfate (HS) polysaccharides are master regulators of diverse biological processes via sulfated motifs that can recruit specific proteins. 3-O-sulfation of HS/heparin is crucial for anticoagulant activity, but despite emerging evidence for roles in many other functions, a lack of tools for d...

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Detalles Bibliográficos
Autores principales: Karlsson, Richard, Chopra, Pradeep, Joshi, Apoorva, Yang, Zhang, Vakhrushev, Sergey Y., Clausen, Thomas Mandel, Painter, Chelsea D., Szekeres, Gergo P., Chen, Yen-Hsi, Sandoval, Daniel R., Hansen, Lars, Esko, Jeffrey D., Pagel, Kevin, Dyer, Douglas P., Turnbull, Jeremy E., Clausen, Henrik, Boons, Geert-Jan, Miller, Rebecca L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694587/
https://www.ncbi.nlm.nih.gov/pubmed/34936441
http://dx.doi.org/10.1126/sciadv.abl6026

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