Endosomal sorting drives the formation of axonal prion protein endoggresomes

The pathogenic aggregation of misfolded prion protein (PrP) in axons underlies prion disease pathologies. The molecular mechanisms driving axonal misfolded PrP aggregate formation leading to neurotoxicity are unknown. We found that the small endolysosomal guanosine triphosphatase (GTPase) Arl8b recr...

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Detalles Bibliográficos
Autores principales: Chassefeyre, Romain, Chaiamarit, Tai, Verhelle, Adriaan, Novak, Sammy Weiser, Andrade, Leonardo R., Leitão, André D. G., Manor, Uri, Encalada, Sandra E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694590/
https://www.ncbi.nlm.nih.gov/pubmed/34936461
http://dx.doi.org/10.1126/sciadv.abg3693

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