Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics

Fibrogenic processes instigate fatal chronic diseases leading to organ failure and death. Underlying biological processes involve induced massive deposition of extracellular matrix (ECM) by aberrant fibroblasts. We subjected diseased primary human lung fibroblasts to an advanced three-dimensional ph...

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Detalles Bibliográficos
Autores principales: Gerckens, Michael, Schorpp, Kenji, Pelizza, Francesco, Wögrath, Melanie, Reichau, Kora, Ma, Huilong, Dworsky, Armando-Marco, Sengupta, Arunima, Stoleriu, Mircea Gabriel, Heinzelmann, Katharina, Merl-Pham, Juliane, Irmler, Martin, Alsafadi, Hani N., Trenkenschuh, Eduard, Sarnova, Lenka, Jirouskova, Marketa, Frieß, Wolfgang, Hauck, Stefanie M., Beckers, Johannes, Kneidinger, Nikolaus, Behr, Jürgen, Hilgendorff, Anne, Hadian, Kamyar, Lindner, Michael, Königshoff, Melanie, Eickelberg, Oliver, Gregor, Martin, Plettenburg, Oliver, Yildirim, Ali Önder, Burgstaller, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694600/
https://www.ncbi.nlm.nih.gov/pubmed/34936468
http://dx.doi.org/10.1126/sciadv.abb3673

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