Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids

We report a method for addition of α-bromophenylacetic acids to vinyl C[double bond, length as m-dash]C bonds in styrenes to afford γ-lactones. Reactions employed a simple cobalt catalyst Co(NO(3))(2)·6H(2)O in the presence of dipivaloylmethane (dpm) ligand. Many functionalities including halogen, e...

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Detalles Bibliográficos
Autores principales: Nguyen, Tung T., Ngo, Bao H. T., Le, Huy X., Vu, Linh N. P., To, Tuong A., Phan, Anh N. Q., Phan, Nam T. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694682/
https://www.ncbi.nlm.nih.gov/pubmed/35423092
http://dx.doi.org/10.1039/d0ra09588e
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author Nguyen, Tung T.
Ngo, Bao H. T.
Le, Huy X.
Vu, Linh N. P.
To, Tuong A.
Phan, Anh N. Q.
Phan, Nam T. S.
author_facet Nguyen, Tung T.
Ngo, Bao H. T.
Le, Huy X.
Vu, Linh N. P.
To, Tuong A.
Phan, Anh N. Q.
Phan, Nam T. S.
author_sort Nguyen, Tung T.
collection PubMed
description We report a method for addition of α-bromophenylacetic acids to vinyl C[double bond, length as m-dash]C bonds in styrenes to afford γ-lactones. Reactions employed a simple cobalt catalyst Co(NO(3))(2)·6H(2)O in the presence of dipivaloylmethane (dpm) ligand. Many functionalities including halogen, ester, and nitro groups were compatible with reaction conditions. If α-bromoesters were used, vinylacetates were the major products.
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spelling pubmed-86946822022-04-13 Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids Nguyen, Tung T. Ngo, Bao H. T. Le, Huy X. Vu, Linh N. P. To, Tuong A. Phan, Anh N. Q. Phan, Nam T. S. RSC Adv Chemistry We report a method for addition of α-bromophenylacetic acids to vinyl C[double bond, length as m-dash]C bonds in styrenes to afford γ-lactones. Reactions employed a simple cobalt catalyst Co(NO(3))(2)·6H(2)O in the presence of dipivaloylmethane (dpm) ligand. Many functionalities including halogen, ester, and nitro groups were compatible with reaction conditions. If α-bromoesters were used, vinylacetates were the major products. The Royal Society of Chemistry 2021-01-29 /pmc/articles/PMC8694682/ /pubmed/35423092 http://dx.doi.org/10.1039/d0ra09588e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Nguyen, Tung T.
Ngo, Bao H. T.
Le, Huy X.
Vu, Linh N. P.
To, Tuong A.
Phan, Anh N. Q.
Phan, Nam T. S.
Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids
title Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids
title_full Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids
title_fullStr Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids
title_full_unstemmed Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids
title_short Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids
title_sort cobalt-catalyzed annulation of styrenes with α-bromoacetic acids
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694682/
https://www.ncbi.nlm.nih.gov/pubmed/35423092
http://dx.doi.org/10.1039/d0ra09588e
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