Ligand-free iridium-catalyzed regioselective C–H borylation of indoles

We herein report a ligand-free Ir-catalyzed C–H borylation of N-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gra...

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Detalles Bibliográficos
Autores principales: Pan, Zilong, Liu, Luhua, Xu, Senmiao, Shen, Zhenlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694714/
https://www.ncbi.nlm.nih.gov/pubmed/35423099
http://dx.doi.org/10.1039/d0ra10211c
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author Pan, Zilong
Liu, Luhua
Xu, Senmiao
Shen, Zhenlu
author_facet Pan, Zilong
Liu, Luhua
Xu, Senmiao
Shen, Zhenlu
author_sort Pan, Zilong
collection PubMed
description We herein report a ligand-free Ir-catalyzed C–H borylation of N-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C–B bonds could be easily converted to C–C and C-heteroatom bonds.
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spelling pubmed-86947142022-04-13 Ligand-free iridium-catalyzed regioselective C–H borylation of indoles Pan, Zilong Liu, Luhua Xu, Senmiao Shen, Zhenlu RSC Adv Chemistry We herein report a ligand-free Ir-catalyzed C–H borylation of N-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C–B bonds could be easily converted to C–C and C-heteroatom bonds. The Royal Society of Chemistry 2021-01-29 /pmc/articles/PMC8694714/ /pubmed/35423099 http://dx.doi.org/10.1039/d0ra10211c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Pan, Zilong
Liu, Luhua
Xu, Senmiao
Shen, Zhenlu
Ligand-free iridium-catalyzed regioselective C–H borylation of indoles
title Ligand-free iridium-catalyzed regioselective C–H borylation of indoles
title_full Ligand-free iridium-catalyzed regioselective C–H borylation of indoles
title_fullStr Ligand-free iridium-catalyzed regioselective C–H borylation of indoles
title_full_unstemmed Ligand-free iridium-catalyzed regioselective C–H borylation of indoles
title_short Ligand-free iridium-catalyzed regioselective C–H borylation of indoles
title_sort ligand-free iridium-catalyzed regioselective c–h borylation of indoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694714/
https://www.ncbi.nlm.nih.gov/pubmed/35423099
http://dx.doi.org/10.1039/d0ra10211c
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AT liuluhua ligandfreeiridiumcatalyzedregioselectivechborylationofindoles
AT xusenmiao ligandfreeiridiumcatalyzedregioselectivechborylationofindoles
AT shenzhenlu ligandfreeiridiumcatalyzedregioselectivechborylationofindoles

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