Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus

The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do n...

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Autores principales: Feng, Xuan, Bello, Davide, O'Hagan, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694766/
https://www.ncbi.nlm.nih.gov/pubmed/35423098
http://dx.doi.org/10.1039/d1ra00235j
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author Feng, Xuan
Bello, Davide
O'Hagan, David
author_facet Feng, Xuan
Bello, Davide
O'Hagan, David
author_sort Feng, Xuan
collection PubMed
description The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.
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spelling pubmed-86947662022-04-13 Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus Feng, Xuan Bello, Davide O'Hagan, David RSC Adv Chemistry The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts. The Royal Society of Chemistry 2021-01-28 /pmc/articles/PMC8694766/ /pubmed/35423098 http://dx.doi.org/10.1039/d1ra00235j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Feng, Xuan
Bello, Davide
O'Hagan, David
Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus
title Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus
title_full Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus
title_fullStr Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus
title_full_unstemmed Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus
title_short Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus
title_sort isolation of 5′-o-sulfamyladenosine and related 3′-o-β-glucosylated adenosines from the nucleocidin producer streptomyces calvus
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694766/
https://www.ncbi.nlm.nih.gov/pubmed/35423098
http://dx.doi.org/10.1039/d1ra00235j
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