Glial fibrillary acidic protein astrocytopathy in a patient with recent mRNA SARS-CoV-2 vaccination: COVERSHEET

BACKGROUND: Literature describing triggers of GFAP astrocytopathy (GFAP-A) is limited. We report a case of GFAP-A in a patient with recent messenger ribonucleic acid (mRNA) severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) vaccination and discuss the possible pathogenesis. CASE DESCRIPTI...

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Autores principales: Koh, Pei Xuan, Tay, Kay Yaw, Yeo, Tianrong, Singh, Dinesh Rambachan, Koh, Jasmine Shimin, Thirugnanam, Umapathi N, Saini, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694819/
http://dx.doi.org/10.1016/j.nerep.2021.100053
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author Koh, Pei Xuan
Tay, Kay Yaw
Yeo, Tianrong
Singh, Dinesh Rambachan
Koh, Jasmine Shimin
Thirugnanam, Umapathi N
Saini, Monica
author_facet Koh, Pei Xuan
Tay, Kay Yaw
Yeo, Tianrong
Singh, Dinesh Rambachan
Koh, Jasmine Shimin
Thirugnanam, Umapathi N
Saini, Monica
author_sort Koh, Pei Xuan
collection PubMed
description BACKGROUND: Literature describing triggers of GFAP astrocytopathy (GFAP-A) is limited. We report a case of GFAP-A in a patient with recent messenger ribonucleic acid (mRNA) severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) vaccination and discuss the possible pathogenesis. CASE DESCRIPTION: A 45-year-old gentleman presented with features of meningoencephalitis 31 days after the first dose and 4 days after the second dose of mRNA SARS-CoV-2 vaccination. He sequentially developed brainstem/cerebellar, autonomic and cord dysfunction. Cerebrospinal fluid was positive for GFAP autoantibody. Clinical improvement occurred after intravenous methylprednisolone and immunoglobulins. CONCLUSION: Although we are uncertain of a causal link of GFAP-A to mRNA vaccine, indirect activation of an underlying dysregulated immune milieu is plausible.
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spelling pubmed-86948192021-12-23 Glial fibrillary acidic protein astrocytopathy in a patient with recent mRNA SARS-CoV-2 vaccination: COVERSHEET Koh, Pei Xuan Tay, Kay Yaw Yeo, Tianrong Singh, Dinesh Rambachan Koh, Jasmine Shimin Thirugnanam, Umapathi N Saini, Monica Neuroimmunology Reports Article BACKGROUND: Literature describing triggers of GFAP astrocytopathy (GFAP-A) is limited. We report a case of GFAP-A in a patient with recent messenger ribonucleic acid (mRNA) severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) vaccination and discuss the possible pathogenesis. CASE DESCRIPTION: A 45-year-old gentleman presented with features of meningoencephalitis 31 days after the first dose and 4 days after the second dose of mRNA SARS-CoV-2 vaccination. He sequentially developed brainstem/cerebellar, autonomic and cord dysfunction. Cerebrospinal fluid was positive for GFAP autoantibody. Clinical improvement occurred after intravenous methylprednisolone and immunoglobulins. CONCLUSION: Although we are uncertain of a causal link of GFAP-A to mRNA vaccine, indirect activation of an underlying dysregulated immune milieu is plausible. The Author(s). Published by Elsevier B.V. 2022 2021-12-22 /pmc/articles/PMC8694819/ http://dx.doi.org/10.1016/j.nerep.2021.100053 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Koh, Pei Xuan
Tay, Kay Yaw
Yeo, Tianrong
Singh, Dinesh Rambachan
Koh, Jasmine Shimin
Thirugnanam, Umapathi N
Saini, Monica
Glial fibrillary acidic protein astrocytopathy in a patient with recent mRNA SARS-CoV-2 vaccination: COVERSHEET
title Glial fibrillary acidic protein astrocytopathy in a patient with recent mRNA SARS-CoV-2 vaccination: COVERSHEET
title_full Glial fibrillary acidic protein astrocytopathy in a patient with recent mRNA SARS-CoV-2 vaccination: COVERSHEET
title_fullStr Glial fibrillary acidic protein astrocytopathy in a patient with recent mRNA SARS-CoV-2 vaccination: COVERSHEET
title_full_unstemmed Glial fibrillary acidic protein astrocytopathy in a patient with recent mRNA SARS-CoV-2 vaccination: COVERSHEET
title_short Glial fibrillary acidic protein astrocytopathy in a patient with recent mRNA SARS-CoV-2 vaccination: COVERSHEET
title_sort glial fibrillary acidic protein astrocytopathy in a patient with recent mrna sars-cov-2 vaccination: coversheet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694819/
http://dx.doi.org/10.1016/j.nerep.2021.100053
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