Vlasoulides A and B, a pair of neuroprotective C(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei

Vlasoulides A and B (1 and 2), a pair of epimeric C(32) sesquiterpene lactone dimers, featuring a 5/7/5/5/(5)/7 ring system were isolated from the roots of Vladimiria souliei. Their chemical structures were determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D N...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Zhi-li, Wang, Qun, Fu, Lu, Su, Ri-xin, Sun, Ze-shi, Li, Hui-liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694822/
https://www.ncbi.nlm.nih.gov/pubmed/35423122
http://dx.doi.org/10.1039/d1ra00075f
Descripción
Sumario:Vlasoulides A and B (1 and 2), a pair of epimeric C(32) sesquiterpene lactone dimers, featuring a 5/7/5/5/(5)/7 ring system were isolated from the roots of Vladimiria souliei. Their chemical structures were determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR spectroscopic data. Their absolute configurations were established by Mosher's method and ECD experiments. Furthermore, biological studies showed that compound 1 showed prominent neuroprotective effects against glutamate-induced neurotoxicity in PC-12 cells, with EC(50) values of 13.54 ± 0.33 μM, while, the EC(50) value of compound 2 is greater than 30 μM.

Ejemplares similares