Vlasoulides A and B, a pair of neuroprotective C(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei

Vlasoulides A and B (1 and 2), a pair of epimeric C(32) sesquiterpene lactone dimers, featuring a 5/7/5/5/(5)/7 ring system were isolated from the roots of Vladimiria souliei. Their chemical structures were determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D N...

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Autores principales: Wu, Zhi-li, Wang, Qun, Fu, Lu, Su, Ri-xin, Sun, Ze-shi, Li, Hui-liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694822/
https://www.ncbi.nlm.nih.gov/pubmed/35423122
http://dx.doi.org/10.1039/d1ra00075f
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author Wu, Zhi-li
Wang, Qun
Fu, Lu
Su, Ri-xin
Sun, Ze-shi
Li, Hui-liang
author_facet Wu, Zhi-li
Wang, Qun
Fu, Lu
Su, Ri-xin
Sun, Ze-shi
Li, Hui-liang
author_sort Wu, Zhi-li
collection PubMed
description Vlasoulides A and B (1 and 2), a pair of epimeric C(32) sesquiterpene lactone dimers, featuring a 5/7/5/5/(5)/7 ring system were isolated from the roots of Vladimiria souliei. Their chemical structures were determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR spectroscopic data. Their absolute configurations were established by Mosher's method and ECD experiments. Furthermore, biological studies showed that compound 1 showed prominent neuroprotective effects against glutamate-induced neurotoxicity in PC-12 cells, with EC(50) values of 13.54 ± 0.33 μM, while, the EC(50) value of compound 2 is greater than 30 μM.
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spelling pubmed-86948222022-04-13 Vlasoulides A and B, a pair of neuroprotective C(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei Wu, Zhi-li Wang, Qun Fu, Lu Su, Ri-xin Sun, Ze-shi Li, Hui-liang RSC Adv Chemistry Vlasoulides A and B (1 and 2), a pair of epimeric C(32) sesquiterpene lactone dimers, featuring a 5/7/5/5/(5)/7 ring system were isolated from the roots of Vladimiria souliei. Their chemical structures were determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR spectroscopic data. Their absolute configurations were established by Mosher's method and ECD experiments. Furthermore, biological studies showed that compound 1 showed prominent neuroprotective effects against glutamate-induced neurotoxicity in PC-12 cells, with EC(50) values of 13.54 ± 0.33 μM, while, the EC(50) value of compound 2 is greater than 30 μM. The Royal Society of Chemistry 2021-02-03 /pmc/articles/PMC8694822/ /pubmed/35423122 http://dx.doi.org/10.1039/d1ra00075f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wu, Zhi-li
Wang, Qun
Fu, Lu
Su, Ri-xin
Sun, Ze-shi
Li, Hui-liang
Vlasoulides A and B, a pair of neuroprotective C(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei
title Vlasoulides A and B, a pair of neuroprotective C(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei
title_full Vlasoulides A and B, a pair of neuroprotective C(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei
title_fullStr Vlasoulides A and B, a pair of neuroprotective C(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei
title_full_unstemmed Vlasoulides A and B, a pair of neuroprotective C(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei
title_short Vlasoulides A and B, a pair of neuroprotective C(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei
title_sort vlasoulides a and b, a pair of neuroprotective c(32) dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of vladimiria souliei
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694822/
https://www.ncbi.nlm.nih.gov/pubmed/35423122
http://dx.doi.org/10.1039/d1ra00075f
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