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From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer
Bioactive carbon dots (C-dots) with ca. 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the “light-up” behaviour enabled them to be explored in glucose detection an...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694864/ https://www.ncbi.nlm.nih.gov/pubmed/35423156 http://dx.doi.org/10.1039/d0ra10859f |
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author | Horst, Frederico Hillesheim Rodrigues, Carime Vitória da Silva Carvalho, Pedro Henrique Pimenta Rocha Leite, Amanda Monteiro Azevedo, Ricardo Bentes Neto, Brenno A. D. Corrêa, José Raimundo Garcia, Mônica Pereira Alotaibi, Saud Henini, Mohamed Chaves, Sacha Braun Rodrigues, Marcelo Oliveira |
author_facet | Horst, Frederico Hillesheim Rodrigues, Carime Vitória da Silva Carvalho, Pedro Henrique Pimenta Rocha Leite, Amanda Monteiro Azevedo, Ricardo Bentes Neto, Brenno A. D. Corrêa, José Raimundo Garcia, Mônica Pereira Alotaibi, Saud Henini, Mohamed Chaves, Sacha Braun Rodrigues, Marcelo Oliveira |
author_sort | Horst, Frederico Hillesheim |
collection | PubMed |
description | Bioactive carbon dots (C-dots) with ca. 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the “light-up” behaviour enabled them to be explored in glucose detection and bioimaging experiments (mitochondrial selective probe). C-dots were not selective to the tumour region and several fluorescent spots were visualized spread on animal bodies. The histology investigations showed that cancer-bearing mice treated with C-dots presented a large number of regions with necrosis and inflammatory infiltrates, which were not identified for cancer-bearing mice without the treatment. These results suggested that C-dots have the potential to be explored as an immune therapy agent for melanoma skin cancer. |
format | Online Article Text |
id | pubmed-8694864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-86948642022-04-13 From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer Horst, Frederico Hillesheim Rodrigues, Carime Vitória da Silva Carvalho, Pedro Henrique Pimenta Rocha Leite, Amanda Monteiro Azevedo, Ricardo Bentes Neto, Brenno A. D. Corrêa, José Raimundo Garcia, Mônica Pereira Alotaibi, Saud Henini, Mohamed Chaves, Sacha Braun Rodrigues, Marcelo Oliveira RSC Adv Chemistry Bioactive carbon dots (C-dots) with ca. 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the “light-up” behaviour enabled them to be explored in glucose detection and bioimaging experiments (mitochondrial selective probe). C-dots were not selective to the tumour region and several fluorescent spots were visualized spread on animal bodies. The histology investigations showed that cancer-bearing mice treated with C-dots presented a large number of regions with necrosis and inflammatory infiltrates, which were not identified for cancer-bearing mice without the treatment. These results suggested that C-dots have the potential to be explored as an immune therapy agent for melanoma skin cancer. The Royal Society of Chemistry 2021-02-03 /pmc/articles/PMC8694864/ /pubmed/35423156 http://dx.doi.org/10.1039/d0ra10859f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Horst, Frederico Hillesheim Rodrigues, Carime Vitória da Silva Carvalho, Pedro Henrique Pimenta Rocha Leite, Amanda Monteiro Azevedo, Ricardo Bentes Neto, Brenno A. D. Corrêa, José Raimundo Garcia, Mônica Pereira Alotaibi, Saud Henini, Mohamed Chaves, Sacha Braun Rodrigues, Marcelo Oliveira From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer |
title | From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer |
title_full | From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer |
title_fullStr | From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer |
title_full_unstemmed | From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer |
title_short | From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer |
title_sort | from cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694864/ https://www.ncbi.nlm.nih.gov/pubmed/35423156 http://dx.doi.org/10.1039/d0ra10859f |
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