Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

Biophysical screening of compound libraries for the identification of ligands that interact with a protein is efficient, but does typically not reveal if (or how) ligands may interfere with its functional properties. For this a biochemical/functional assay is required. But for proteins whose functio...

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Detalles Bibliográficos
Autores principales: FitzGerald, Edward A., Butko, Margaret T., Boronat, Pierre, Cederfelt, Daniela, Abramsson, Mia, Ludviksdottir, Hildur, van Muijlwijk-Koezen, Jacqueline E., de Esch, Iwan J. P., Dobritzsch, Doreen, Young, Tracy, Danielson, U. Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694943/
https://www.ncbi.nlm.nih.gov/pubmed/35423271
http://dx.doi.org/10.1039/d0ra09844b

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