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Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk

Taking thiamphenicol as the research object, a new type of magnetic restricted access molecularly imprinted polymer (RAM-MMIP) with specific recognition was prepared by a one-step swelling method. The polymer microspheres were characterized and analyzed by scanning electron microscopy, X-ray diffrac...

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Autores principales: Zhang, Shuai, Liu, Huachun, Cai, Tianpei, Zhou, Yanqiang, Li, Jianmin, Wang, Xiaoxiao, Zhao, Shanwen, Bo, Chunmiao, Gong, Bolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695050/
https://www.ncbi.nlm.nih.gov/pubmed/35423174
http://dx.doi.org/10.1039/d0ra10268g
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author Zhang, Shuai
Liu, Huachun
Cai, Tianpei
Zhou, Yanqiang
Li, Jianmin
Wang, Xiaoxiao
Zhao, Shanwen
Bo, Chunmiao
Gong, Bolin
author_facet Zhang, Shuai
Liu, Huachun
Cai, Tianpei
Zhou, Yanqiang
Li, Jianmin
Wang, Xiaoxiao
Zhao, Shanwen
Bo, Chunmiao
Gong, Bolin
author_sort Zhang, Shuai
collection PubMed
description Taking thiamphenicol as the research object, a new type of magnetic restricted access molecularly imprinted polymer (RAM-MMIP) with specific recognition was prepared by a one-step swelling method. The polymer microspheres were characterized and analyzed by scanning electron microscopy, X-ray diffraction, elemental analysis, contact angle measurement and vibrating sample magnetometry. When the ratio of template molecule, functional monomer and cross linking agent was 1 : 4 : 8, the adsorption capacity reached the maximum. Under these conditions, RAM-MIP magnetic solid phase extraction (M-SPE) was combined with HPLC to analyze thiamphenicol in milk samples. Satisfactory linear correlation (R(2) > 0.9977), good detection limit (LOD: 10.4 μg L(−1)), high recovery rate (96.5–101.1%), and relative standard deviation (RSD: 2.8–3.8%) were obtained. Therefore, our synthesized material can be used for the analysis of TAP in complex milk samples, and has broad application value.
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spelling pubmed-86950502022-04-13 Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk Zhang, Shuai Liu, Huachun Cai, Tianpei Zhou, Yanqiang Li, Jianmin Wang, Xiaoxiao Zhao, Shanwen Bo, Chunmiao Gong, Bolin RSC Adv Chemistry Taking thiamphenicol as the research object, a new type of magnetic restricted access molecularly imprinted polymer (RAM-MMIP) with specific recognition was prepared by a one-step swelling method. The polymer microspheres were characterized and analyzed by scanning electron microscopy, X-ray diffraction, elemental analysis, contact angle measurement and vibrating sample magnetometry. When the ratio of template molecule, functional monomer and cross linking agent was 1 : 4 : 8, the adsorption capacity reached the maximum. Under these conditions, RAM-MIP magnetic solid phase extraction (M-SPE) was combined with HPLC to analyze thiamphenicol in milk samples. Satisfactory linear correlation (R(2) > 0.9977), good detection limit (LOD: 10.4 μg L(−1)), high recovery rate (96.5–101.1%), and relative standard deviation (RSD: 2.8–3.8%) were obtained. Therefore, our synthesized material can be used for the analysis of TAP in complex milk samples, and has broad application value. The Royal Society of Chemistry 2021-02-10 /pmc/articles/PMC8695050/ /pubmed/35423174 http://dx.doi.org/10.1039/d0ra10268g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhang, Shuai
Liu, Huachun
Cai, Tianpei
Zhou, Yanqiang
Li, Jianmin
Wang, Xiaoxiao
Zhao, Shanwen
Bo, Chunmiao
Gong, Bolin
Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk
title Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk
title_full Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk
title_fullStr Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk
title_full_unstemmed Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk
title_short Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk
title_sort synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695050/
https://www.ncbi.nlm.nih.gov/pubmed/35423174
http://dx.doi.org/10.1039/d0ra10268g
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