Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles

We report a method for directed ortho-arylation of N-aryl pyrazoles with arylboronic acids. Reactions proceeded in the presence of a Co(hfacac)(2) catalyst, CeSO(4) oxidant, and HFIP solvent. Functionalities such as nitro, ester, bromo, and ketone groups were compatible with the reaction conditions....

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Detalles Bibliográficos
Autores principales: Nguyen, Tung T., Le, Lam V., Pham, Hai H., Nguyen, Dung H., Phan, Nam T. S., Le, Ha V., Phan, Anh N. Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695287/
https://www.ncbi.nlm.nih.gov/pubmed/35423432
http://dx.doi.org/10.1039/d1ra00975c
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author Nguyen, Tung T.
Le, Lam V.
Pham, Hai H.
Nguyen, Dung H.
Phan, Nam T. S.
Le, Ha V.
Phan, Anh N. Q.
author_facet Nguyen, Tung T.
Le, Lam V.
Pham, Hai H.
Nguyen, Dung H.
Phan, Nam T. S.
Le, Ha V.
Phan, Anh N. Q.
author_sort Nguyen, Tung T.
collection PubMed
description We report a method for directed ortho-arylation of N-aryl pyrazoles with arylboronic acids. Reactions proceeded in the presence of a Co(hfacac)(2) catalyst, CeSO(4) oxidant, and HFIP solvent. Functionalities such as nitro, ester, bromo, and ketone groups were compatible with the reaction conditions. Using heterocycles including thiophene and carbazole was also feasible.
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spelling pubmed-86952872022-04-13 Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles Nguyen, Tung T. Le, Lam V. Pham, Hai H. Nguyen, Dung H. Phan, Nam T. S. Le, Ha V. Phan, Anh N. Q. RSC Adv Chemistry We report a method for directed ortho-arylation of N-aryl pyrazoles with arylboronic acids. Reactions proceeded in the presence of a Co(hfacac)(2) catalyst, CeSO(4) oxidant, and HFIP solvent. Functionalities such as nitro, ester, bromo, and ketone groups were compatible with the reaction conditions. Using heterocycles including thiophene and carbazole was also feasible. The Royal Society of Chemistry 2021-03-01 /pmc/articles/PMC8695287/ /pubmed/35423432 http://dx.doi.org/10.1039/d1ra00975c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Nguyen, Tung T.
Le, Lam V.
Pham, Hai H.
Nguyen, Dung H.
Phan, Nam T. S.
Le, Ha V.
Phan, Anh N. Q.
Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles
title Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles
title_full Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles
title_fullStr Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles
title_full_unstemmed Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles
title_short Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles
title_sort cobalt-catalyzed, directed arylation of c–h bonds in n-aryl pyrazoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695287/
https://www.ncbi.nlm.nih.gov/pubmed/35423432
http://dx.doi.org/10.1039/d1ra00975c
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