Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones

Fast and simple access to N-arylated 3-hydroxyquinolin-4(1H)-ones starting from easily available 1-methyl-2-iodoterephthalate and variously substituted anilines is presented. N-Alkylated anthranilic acid derivatives represent important intermediates. They can be advantageously prepared by solid-phas...

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Autores principales: Krajčovičová, Soňa, Hlaváč, Jan, Vychodilová, Kristýna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695337/
https://www.ncbi.nlm.nih.gov/pubmed/35423420
http://dx.doi.org/10.1039/d1ra01308d
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author Krajčovičová, Soňa
Hlaváč, Jan
Vychodilová, Kristýna
author_facet Krajčovičová, Soňa
Hlaváč, Jan
Vychodilová, Kristýna
author_sort Krajčovičová, Soňa
collection PubMed
description Fast and simple access to N-arylated 3-hydroxyquinolin-4(1H)-ones starting from easily available 1-methyl-2-iodoterephthalate and variously substituted anilines is presented. N-Alkylated anthranilic acid derivatives represent important intermediates. They can be advantageously prepared by solid-phase synthesis, by Buchwald–Hartwig amination or reductive amination with wide substrate scope and with excellent crude purities.
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spelling pubmed-86953372022-04-13 Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones Krajčovičová, Soňa Hlaváč, Jan Vychodilová, Kristýna RSC Adv Chemistry Fast and simple access to N-arylated 3-hydroxyquinolin-4(1H)-ones starting from easily available 1-methyl-2-iodoterephthalate and variously substituted anilines is presented. N-Alkylated anthranilic acid derivatives represent important intermediates. They can be advantageously prepared by solid-phase synthesis, by Buchwald–Hartwig amination or reductive amination with wide substrate scope and with excellent crude purities. The Royal Society of Chemistry 2021-03-02 /pmc/articles/PMC8695337/ /pubmed/35423420 http://dx.doi.org/10.1039/d1ra01308d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Krajčovičová, Soňa
Hlaváč, Jan
Vychodilová, Kristýna
Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones
title Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones
title_full Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones
title_fullStr Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones
title_full_unstemmed Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones
title_short Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones
title_sort polymer-supported synthesis of n-substituted anthranilates as the building blocks for preparation of n-arylated 3-hydroxyquinolin-4(1h)-ones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695337/
https://www.ncbi.nlm.nih.gov/pubmed/35423420
http://dx.doi.org/10.1039/d1ra01308d
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AT vychodilovakristyna polymersupportedsynthesisofnsubstitutedanthranilatesasthebuildingblocksforpreparationofnarylated3hydroxyquinolin41hones

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