Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system

The incidence of central nervous system (CNS) diseases is increasing with the aging population. However, it remains challenging to deliver drugs into the CNS because of the existence of a blood–brain barrier (BBB). Notably, rabies virus glycoprotein (RVG) peptides have been developed as delivery lig...

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Autores principales: Wang, Qinghua, Cheng, Shang, Qin, Fen, Fu, Ailing, Fu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695342/
https://www.ncbi.nlm.nih.gov/pubmed/35423368
http://dx.doi.org/10.1039/d1ra00550b
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author Wang, Qinghua
Cheng, Shang
Qin, Fen
Fu, Ailing
Fu, Chen
author_facet Wang, Qinghua
Cheng, Shang
Qin, Fen
Fu, Ailing
Fu, Chen
author_sort Wang, Qinghua
collection PubMed
description The incidence of central nervous system (CNS) diseases is increasing with the aging population. However, it remains challenging to deliver drugs into the CNS because of the existence of a blood–brain barrier (BBB). Notably, rabies virus glycoprotein (RVG) peptides have been developed as delivery ligands for CNS diseases. So far, massive RVG peptide modified carriers have been reported, such as liposomes, micelles, polymers, exosomes, dendrimers, and proteins. Moreover, these drug delivery systems can encapsulate almost all small molecules and macromolecule drugs, including siRNA, microRNAs, DNA, proteins, and other nanoparticles, to treat various CNS diseases with efficient and safe drugs. In this review, targeted delivery systems with RVG peptide modified carriers possessing favorable biocompatibility and delivery efficiency are summarized.
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spelling pubmed-86953422022-04-13 Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system Wang, Qinghua Cheng, Shang Qin, Fen Fu, Ailing Fu, Chen RSC Adv Chemistry The incidence of central nervous system (CNS) diseases is increasing with the aging population. However, it remains challenging to deliver drugs into the CNS because of the existence of a blood–brain barrier (BBB). Notably, rabies virus glycoprotein (RVG) peptides have been developed as delivery ligands for CNS diseases. So far, massive RVG peptide modified carriers have been reported, such as liposomes, micelles, polymers, exosomes, dendrimers, and proteins. Moreover, these drug delivery systems can encapsulate almost all small molecules and macromolecule drugs, including siRNA, microRNAs, DNA, proteins, and other nanoparticles, to treat various CNS diseases with efficient and safe drugs. In this review, targeted delivery systems with RVG peptide modified carriers possessing favorable biocompatibility and delivery efficiency are summarized. The Royal Society of Chemistry 2021-02-24 /pmc/articles/PMC8695342/ /pubmed/35423368 http://dx.doi.org/10.1039/d1ra00550b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wang, Qinghua
Cheng, Shang
Qin, Fen
Fu, Ailing
Fu, Chen
Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system
title Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system
title_full Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system
title_fullStr Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system
title_full_unstemmed Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system
title_short Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system
title_sort application progress of rvg peptides to facilitate the delivery of therapeutic agents into the central nervous system
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695342/
https://www.ncbi.nlm.nih.gov/pubmed/35423368
http://dx.doi.org/10.1039/d1ra00550b
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