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Cytotoxicity of targeted PLGA nanoparticles: a systematic review

Recent advances in nanotechnology have contributed tremendously to the development and revolutionizing of drug delivery systems in the field of nanomedicine. In particular, targeting nanoparticles based on biodegradable poly(lactic-co-glycolic acid) (PLGA) polymers have gained much interest. However...

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Autores principales: Chiu, Hock Ing, Samad, Nozlena Abdul, Fang, Lizhen, Lim, Vuanghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695459/
https://www.ncbi.nlm.nih.gov/pubmed/35423427
http://dx.doi.org/10.1039/d1ra00074h
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author Chiu, Hock Ing
Samad, Nozlena Abdul
Fang, Lizhen
Lim, Vuanghao
author_facet Chiu, Hock Ing
Samad, Nozlena Abdul
Fang, Lizhen
Lim, Vuanghao
author_sort Chiu, Hock Ing
collection PubMed
description Recent advances in nanotechnology have contributed tremendously to the development and revolutionizing of drug delivery systems in the field of nanomedicine. In particular, targeting nanoparticles based on biodegradable poly(lactic-co-glycolic acid) (PLGA) polymers have gained much interest. However, PLGA nanoparticles remain of concern for their effectiveness against cancer cells and their toxicity to normal cells. The aim of this systematic review is to identify a promising targeting PLGA nanoformulation based on the comparison study of their cytotoxicity potency in different cell lines. A literature search was conducted through the databases of Google Scholar, PubMed, ScienceDirect, Scopus and SpringerLink. The sources studied were published between 2009 and 2019, and a variety of keywords were utilized. In total, 81 manuscripts that met the inclusion and exclusion criteria were selected for analysis based on their cytotoxicity, size, zeta potential, year of publication, type of ligand, active compounds and cell line used. The half maximal inhibitory concentration (IC(50)) for cytotoxicity was the main measurement in this data extraction, and the SI units were standardized to μg mL(−1) for a better view of comparison. This systematic review also identified that cytotoxicity potency was inversely proportional to nanoparticle size. The PLGA nanoparticles predominantly exhibited a size of less than 300 nm and absolute zeta potential ∼20 mV. In conclusion, more comprehensive and critical appraisals of pharmacokinetic, pharmacokinetic, toxicokinetic, in vivo and in vitro tests are required for the investigation of the full value of targeting PLGA nanoparticles for cancer treatment.
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spelling pubmed-86954592022-04-13 Cytotoxicity of targeted PLGA nanoparticles: a systematic review Chiu, Hock Ing Samad, Nozlena Abdul Fang, Lizhen Lim, Vuanghao RSC Adv Chemistry Recent advances in nanotechnology have contributed tremendously to the development and revolutionizing of drug delivery systems in the field of nanomedicine. In particular, targeting nanoparticles based on biodegradable poly(lactic-co-glycolic acid) (PLGA) polymers have gained much interest. However, PLGA nanoparticles remain of concern for their effectiveness against cancer cells and their toxicity to normal cells. The aim of this systematic review is to identify a promising targeting PLGA nanoformulation based on the comparison study of their cytotoxicity potency in different cell lines. A literature search was conducted through the databases of Google Scholar, PubMed, ScienceDirect, Scopus and SpringerLink. The sources studied were published between 2009 and 2019, and a variety of keywords were utilized. In total, 81 manuscripts that met the inclusion and exclusion criteria were selected for analysis based on their cytotoxicity, size, zeta potential, year of publication, type of ligand, active compounds and cell line used. The half maximal inhibitory concentration (IC(50)) for cytotoxicity was the main measurement in this data extraction, and the SI units were standardized to μg mL(−1) for a better view of comparison. This systematic review also identified that cytotoxicity potency was inversely proportional to nanoparticle size. The PLGA nanoparticles predominantly exhibited a size of less than 300 nm and absolute zeta potential ∼20 mV. In conclusion, more comprehensive and critical appraisals of pharmacokinetic, pharmacokinetic, toxicokinetic, in vivo and in vitro tests are required for the investigation of the full value of targeting PLGA nanoparticles for cancer treatment. The Royal Society of Chemistry 2021-03-03 /pmc/articles/PMC8695459/ /pubmed/35423427 http://dx.doi.org/10.1039/d1ra00074h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Chiu, Hock Ing
Samad, Nozlena Abdul
Fang, Lizhen
Lim, Vuanghao
Cytotoxicity of targeted PLGA nanoparticles: a systematic review
title Cytotoxicity of targeted PLGA nanoparticles: a systematic review
title_full Cytotoxicity of targeted PLGA nanoparticles: a systematic review
title_fullStr Cytotoxicity of targeted PLGA nanoparticles: a systematic review
title_full_unstemmed Cytotoxicity of targeted PLGA nanoparticles: a systematic review
title_short Cytotoxicity of targeted PLGA nanoparticles: a systematic review
title_sort cytotoxicity of targeted plga nanoparticles: a systematic review
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695459/
https://www.ncbi.nlm.nih.gov/pubmed/35423427
http://dx.doi.org/10.1039/d1ra00074h
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AT fanglizhen cytotoxicityoftargetedplgananoparticlesasystematicreview
AT limvuanghao cytotoxicityoftargetedplgananoparticlesasystematicreview