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Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of (18)F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer
BACKGROUND: The role of (18)F-flurodeoxyglucose ((18)F-FDG) positron emission tomography–computed tomography (PET/CT) in colorectal cancer (CRC) remains unclear. This study aimed to explore the association of the maximum standardized uptake value (SUVmax), a parameter of (18)F-FDG PET/CT, with KRAS...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695495/ https://www.ncbi.nlm.nih.gov/pubmed/34956868 http://dx.doi.org/10.3389/fonc.2021.741612 |
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author | Yin, Yi-xin Xie, Ming-zhi Liang, Xin-qiang Ye, Meng-ling Li, Ji-lin Hu, Bang-li |
author_facet | Yin, Yi-xin Xie, Ming-zhi Liang, Xin-qiang Ye, Meng-ling Li, Ji-lin Hu, Bang-li |
author_sort | Yin, Yi-xin |
collection | PubMed |
description | BACKGROUND: The role of (18)F-flurodeoxyglucose ((18)F-FDG) positron emission tomography–computed tomography (PET/CT) in colorectal cancer (CRC) remains unclear. This study aimed to explore the association of the maximum standardized uptake value (SUVmax), a parameter of (18)F-FDG PET/CT, with KRAS mutation, the Ki-67 index, and survival in patients with CRC. METHODS: Data of 66 patients with CRC who underwent (18)F-FDG PET/CT was retrospectively collected in our center. The clinical significance of the SUVmax in CRC and the association of the SUVmax with KRAS mutation and the Ki-67 index were determined. A meta-analysis was conducted by a systematic search of PubMed, Web of Science, and CNKI databases, and the data from published articles were combined with that of our study. The association of the SUVmax with KRAS mutation and the Ki-67 index was determined using the odds ratio to estimate the pooled results. The hazard ratio was used to quantitatively evaluate the prognosis of the SUVmax in CRC. RESULTS: By analyzing the data of 66 patients with CRC, the SUVmax was found not to be related to the tumor-node-metastasis stage, clinical stage, sex, and KRAS mutation but was related to the tumor location and nerve invasion. The SUVmax had no significant correlation with the tumor biomarkers and the Ki-67 index. Data of 17 studies indicated that the SUVmax was significantly increased in the mutated type compared with the wild type of KRAS in CRC; four studies showed that there was no remarkable difference between patients with a high and low Ki-67 index score regarding the SUVmax. Twelve studies revealed that the SUVmax had no significant association with overall survival and disease-free survival in CRC patients. CONCLUSIONS: Based on the combined data, this study demonstrated that the SUVmax of (18)F-FDG PET/CT was different between colon and rectal cancers and associated with KRAS mutation but not the Ki-67 index; there was no significant association between the SUVmax and survival of patients with CRC. |
format | Online Article Text |
id | pubmed-8695495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86954952021-12-24 Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of (18)F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer Yin, Yi-xin Xie, Ming-zhi Liang, Xin-qiang Ye, Meng-ling Li, Ji-lin Hu, Bang-li Front Oncol Oncology BACKGROUND: The role of (18)F-flurodeoxyglucose ((18)F-FDG) positron emission tomography–computed tomography (PET/CT) in colorectal cancer (CRC) remains unclear. This study aimed to explore the association of the maximum standardized uptake value (SUVmax), a parameter of (18)F-FDG PET/CT, with KRAS mutation, the Ki-67 index, and survival in patients with CRC. METHODS: Data of 66 patients with CRC who underwent (18)F-FDG PET/CT was retrospectively collected in our center. The clinical significance of the SUVmax in CRC and the association of the SUVmax with KRAS mutation and the Ki-67 index were determined. A meta-analysis was conducted by a systematic search of PubMed, Web of Science, and CNKI databases, and the data from published articles were combined with that of our study. The association of the SUVmax with KRAS mutation and the Ki-67 index was determined using the odds ratio to estimate the pooled results. The hazard ratio was used to quantitatively evaluate the prognosis of the SUVmax in CRC. RESULTS: By analyzing the data of 66 patients with CRC, the SUVmax was found not to be related to the tumor-node-metastasis stage, clinical stage, sex, and KRAS mutation but was related to the tumor location and nerve invasion. The SUVmax had no significant correlation with the tumor biomarkers and the Ki-67 index. Data of 17 studies indicated that the SUVmax was significantly increased in the mutated type compared with the wild type of KRAS in CRC; four studies showed that there was no remarkable difference between patients with a high and low Ki-67 index score regarding the SUVmax. Twelve studies revealed that the SUVmax had no significant association with overall survival and disease-free survival in CRC patients. CONCLUSIONS: Based on the combined data, this study demonstrated that the SUVmax of (18)F-FDG PET/CT was different between colon and rectal cancers and associated with KRAS mutation but not the Ki-67 index; there was no significant association between the SUVmax and survival of patients with CRC. Frontiers Media S.A. 2021-12-09 /pmc/articles/PMC8695495/ /pubmed/34956868 http://dx.doi.org/10.3389/fonc.2021.741612 Text en Copyright © 2021 Yin, Xie, Liang, Ye, Li and Hu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Yin, Yi-xin Xie, Ming-zhi Liang, Xin-qiang Ye, Meng-ling Li, Ji-lin Hu, Bang-li Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of (18)F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer |
title | Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of (18)F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer |
title_full | Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of (18)F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer |
title_fullStr | Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of (18)F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer |
title_full_unstemmed | Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of (18)F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer |
title_short | Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of (18)F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer |
title_sort | clinical significance and prognostic value of the maximum standardized uptake value of (18)f-flurodeoxyglucose positron emission tomography–computed tomography in colorectal cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695495/ https://www.ncbi.nlm.nih.gov/pubmed/34956868 http://dx.doi.org/10.3389/fonc.2021.741612 |
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