Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones

An expeditious metal free C-3 chalcogenation of 4H-pyrido[1,2-a]pyrimidin-4-one has been devised to synthesize diversely orchestrated 3-ArS/ArSe derivatives in high yields (up to 95%). This operationally simple reaction proceeds under mild reaction conditions, can be executed in gram scale, and also...

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Detalles Bibliográficos
Autores principales: Ghosh, Prasanjit, Chhetri, Gautam, Das, Sajal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695620/
https://www.ncbi.nlm.nih.gov/pubmed/35423521
http://dx.doi.org/10.1039/d1ra00834j
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author Ghosh, Prasanjit
Chhetri, Gautam
Das, Sajal
author_facet Ghosh, Prasanjit
Chhetri, Gautam
Das, Sajal
author_sort Ghosh, Prasanjit
collection PubMed
description An expeditious metal free C-3 chalcogenation of 4H-pyrido[1,2-a]pyrimidin-4-one has been devised to synthesize diversely orchestrated 3-ArS/ArSe derivatives in high yields (up to 95%). This operationally simple reaction proceeds under mild reaction conditions, can be executed in gram scale, and also highlights broad functional group tolerance. Preliminary experimental investigation suggests a radical mechanistic pathway for these transformations.
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spelling pubmed-86956202022-04-13 Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones Ghosh, Prasanjit Chhetri, Gautam Das, Sajal RSC Adv Chemistry An expeditious metal free C-3 chalcogenation of 4H-pyrido[1,2-a]pyrimidin-4-one has been devised to synthesize diversely orchestrated 3-ArS/ArSe derivatives in high yields (up to 95%). This operationally simple reaction proceeds under mild reaction conditions, can be executed in gram scale, and also highlights broad functional group tolerance. Preliminary experimental investigation suggests a radical mechanistic pathway for these transformations. The Royal Society of Chemistry 2021-03-09 /pmc/articles/PMC8695620/ /pubmed/35423521 http://dx.doi.org/10.1039/d1ra00834j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Ghosh, Prasanjit
Chhetri, Gautam
Das, Sajal
Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones
title Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones
title_full Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones
title_fullStr Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones
title_full_unstemmed Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones
title_short Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones
title_sort metal free c-3 chalcogenation (sulfenylation and selenylation) of 4h-pyrido[1,2-a]pyrimidin-4-ones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695620/
https://www.ncbi.nlm.nih.gov/pubmed/35423521
http://dx.doi.org/10.1039/d1ra00834j
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AT dassajal metalfreec3chalcogenationsulfenylationandselenylationof4hpyrido12apyrimidin4ones

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