SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination

SARS-CoV-2 antibodies in saliva serve as first line of defense against the virus. They are present in the mucosa, more precisely in saliva, after a recovered infection and also following vaccination. We report here the antibody persistence in plasma and in saliva up to 15 months after mild COVID-19....

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Autores principales: Pinilla, Yudi T., Heinzel, Constanze, Caminada, Lena-Fabienne, Consolaro, Douglas, Esen, Meral, Kremsner, Peter G., Held, Jana, Kreidenweiss, Andrea, Fendel, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695841/
https://www.ncbi.nlm.nih.gov/pubmed/34956236
http://dx.doi.org/10.3389/fimmu.2021.798859
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author Pinilla, Yudi T.
Heinzel, Constanze
Caminada, Lena-Fabienne
Consolaro, Douglas
Esen, Meral
Kremsner, Peter G.
Held, Jana
Kreidenweiss, Andrea
Fendel, Rolf
author_facet Pinilla, Yudi T.
Heinzel, Constanze
Caminada, Lena-Fabienne
Consolaro, Douglas
Esen, Meral
Kremsner, Peter G.
Held, Jana
Kreidenweiss, Andrea
Fendel, Rolf
author_sort Pinilla, Yudi T.
collection PubMed
description SARS-CoV-2 antibodies in saliva serve as first line of defense against the virus. They are present in the mucosa, more precisely in saliva, after a recovered infection and also following vaccination. We report here the antibody persistence in plasma and in saliva up to 15 months after mild COVID-19. The IgG antibody response was measured every two months in 72 participants using an established and validated in-house ELISA assay. In addition, the virus inhibitory activity of plasma antibodies was assessed in a surrogate virus neutralization test before and after vaccination. SARS-CoV-2-specific antibody concentrations remained stable in plasma and saliva and the response was strongly boosted after one dose COVID-19 vaccination.
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spelling pubmed-86958412021-12-24 SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination Pinilla, Yudi T. Heinzel, Constanze Caminada, Lena-Fabienne Consolaro, Douglas Esen, Meral Kremsner, Peter G. Held, Jana Kreidenweiss, Andrea Fendel, Rolf Front Immunol Immunology SARS-CoV-2 antibodies in saliva serve as first line of defense against the virus. They are present in the mucosa, more precisely in saliva, after a recovered infection and also following vaccination. We report here the antibody persistence in plasma and in saliva up to 15 months after mild COVID-19. The IgG antibody response was measured every two months in 72 participants using an established and validated in-house ELISA assay. In addition, the virus inhibitory activity of plasma antibodies was assessed in a surrogate virus neutralization test before and after vaccination. SARS-CoV-2-specific antibody concentrations remained stable in plasma and saliva and the response was strongly boosted after one dose COVID-19 vaccination. Frontiers Media S.A. 2021-12-09 /pmc/articles/PMC8695841/ /pubmed/34956236 http://dx.doi.org/10.3389/fimmu.2021.798859 Text en Copyright © 2021 Pinilla, Heinzel, Caminada, Consolaro, Esen, Kremsner, Held, Kreidenweiss and Fendel https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Pinilla, Yudi T.
Heinzel, Constanze
Caminada, Lena-Fabienne
Consolaro, Douglas
Esen, Meral
Kremsner, Peter G.
Held, Jana
Kreidenweiss, Andrea
Fendel, Rolf
SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination
title SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination
title_full SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination
title_fullStr SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination
title_full_unstemmed SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination
title_short SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination
title_sort sars-cov-2 antibodies are persisting in saliva for more than 15 months after infection and become strongly boosted after vaccination
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695841/
https://www.ncbi.nlm.nih.gov/pubmed/34956236
http://dx.doi.org/10.3389/fimmu.2021.798859
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