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The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility

Although the association of MEG3 gene rs7158663 polymorphism with cancer susceptibility has been investigated, the findings are inconsistent. The aim of this study was to analyze the association between the rs7158663 polymorphism and cancer susceptibility through a case-control study and meta-analys...

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Autores principales: Gao, Xueren, Li, Xianyang, Zhang, Shulong, Wang, Xiaoting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695896/
https://www.ncbi.nlm.nih.gov/pubmed/34956908
http://dx.doi.org/10.3389/fonc.2021.796774
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author Gao, Xueren
Li, Xianyang
Zhang, Shulong
Wang, Xiaoting
author_facet Gao, Xueren
Li, Xianyang
Zhang, Shulong
Wang, Xiaoting
author_sort Gao, Xueren
collection PubMed
description Although the association of MEG3 gene rs7158663 polymorphism with cancer susceptibility has been investigated, the findings are inconsistent. The aim of this study was to analyze the association between the rs7158663 polymorphism and cancer susceptibility through a case-control study and meta-analysis. In a case-control study with 430 colorectal cancer (CRC) cases and 445 healthy controls, the rs7158663 polymorphism was genotyped by direct sequencing. STATA software was used to calculate the pooled odds ratio and 95% confidence interval in a meta-analysis including 4,649 cancer cases and 5,590 controls. Both the case-control study and meta-analysis showed that the rs7158663 polymorphism was associated with increased susceptibility to CRC. Individuals carrying the AA or GA genotype were more likely to develop CRC than those carrying the rs7158663 GG genotype. Interestingly, MEG3 expression was significantly lower in colorectal tissues of the AA or GA genotype compared to those of the rs7158663 GG genotype. In addition, the meta-analysis suggested that the rs7158663 polymorphism was also associated with increased susceptibility to breast cancer and gastric cancer. Bioinformatics analysis showed that the rs7158663 A allele contributed to the binding of hsa-miR-4307 and hsa-miR-1265 to MEG3. In conclusion, the current findings suggest that the MEG3 gene rs7158663 polymorphism may serve as a genetic marker for predicting the risk of cancers, such as breast cancer, gastric cancer and CRC. However, the sample size of the current study is still insufficient, especially in the subgroup analysis. Therefore large and well-designed studies are needed to validate our findings.
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spelling pubmed-86958962021-12-24 The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility Gao, Xueren Li, Xianyang Zhang, Shulong Wang, Xiaoting Front Oncol Oncology Although the association of MEG3 gene rs7158663 polymorphism with cancer susceptibility has been investigated, the findings are inconsistent. The aim of this study was to analyze the association between the rs7158663 polymorphism and cancer susceptibility through a case-control study and meta-analysis. In a case-control study with 430 colorectal cancer (CRC) cases and 445 healthy controls, the rs7158663 polymorphism was genotyped by direct sequencing. STATA software was used to calculate the pooled odds ratio and 95% confidence interval in a meta-analysis including 4,649 cancer cases and 5,590 controls. Both the case-control study and meta-analysis showed that the rs7158663 polymorphism was associated with increased susceptibility to CRC. Individuals carrying the AA or GA genotype were more likely to develop CRC than those carrying the rs7158663 GG genotype. Interestingly, MEG3 expression was significantly lower in colorectal tissues of the AA or GA genotype compared to those of the rs7158663 GG genotype. In addition, the meta-analysis suggested that the rs7158663 polymorphism was also associated with increased susceptibility to breast cancer and gastric cancer. Bioinformatics analysis showed that the rs7158663 A allele contributed to the binding of hsa-miR-4307 and hsa-miR-1265 to MEG3. In conclusion, the current findings suggest that the MEG3 gene rs7158663 polymorphism may serve as a genetic marker for predicting the risk of cancers, such as breast cancer, gastric cancer and CRC. However, the sample size of the current study is still insufficient, especially in the subgroup analysis. Therefore large and well-designed studies are needed to validate our findings. Frontiers Media S.A. 2021-12-09 /pmc/articles/PMC8695896/ /pubmed/34956908 http://dx.doi.org/10.3389/fonc.2021.796774 Text en Copyright © 2021 Gao, Li, Zhang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Gao, Xueren
Li, Xianyang
Zhang, Shulong
Wang, Xiaoting
The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility
title The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility
title_full The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility
title_fullStr The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility
title_full_unstemmed The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility
title_short The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility
title_sort association of meg3 gene rs7158663 polymorphism with cancer susceptibility
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695896/
https://www.ncbi.nlm.nih.gov/pubmed/34956908
http://dx.doi.org/10.3389/fonc.2021.796774
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