Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case

A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and t...

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Detalles Bibliográficos
Autores principales: Vannella, Kevin M., Oguz, Cihan, Stein, Sydney R., Pittaluga, Stefania, Dikoglu, Esra, Kanwal, Arjun, Ramelli, Sabrina C., Briese, Thomas, Su, Ling, Wu, Xiaolin, Ramos-Benitez, Marcos J., Perez-Valencia, Luis J., Babyak, Ashley, Cha, Nu Ri, Chung, Joon-Yong, Ylaya, Kris, Madathil, Ronson J., Saharia, Kapil K., Scalea, Thomas M., Tran, Quincy K., Herr, Daniel L., Kleiner, David E., Hewitt, Stephen M., Notarangelo, Luigi D., Grazioli, Alison, Chertow, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695925/
https://www.ncbi.nlm.nih.gov/pubmed/34956207
http://dx.doi.org/10.3389/fimmu.2021.779026
Descripción
Sumario:A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis.

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