YAP/TAZ: Key Players for Rheumatoid Arthritis Severity by Driving Fibroblast Like Synoviocytes Phenotype and Fibro-Inflammatory Response

OBJECTIVE: The role of YAP/TAZ, two transcriptional co-activators involved in several cancers, was investigated in rheumatoid arthritis (RA). METHODS: Fibroblast like synoviocytes (FLS) from patients with RA or osteoarthritis were cultured in 2D or into 3D synovial organoids. Arthritis rat model (n=...

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Detalles Bibliográficos
Autores principales: Caire, Robin, Audoux, Estelle, Courbon, Guillaume, Michaud, Eva, Petit, Claudie, Dalix, Elisa, Chafchafi, Marwa, Thomas, Mireille, Vanden-Bossche, Arnaud, Navarro, Laurent, Linossier, Marie-Thérèse, Peyroche, Sylvie, Guignandon, Alain, Vico, Laurence, Paul, Stephane, Marotte, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695934/
https://www.ncbi.nlm.nih.gov/pubmed/34956224
http://dx.doi.org/10.3389/fimmu.2021.791907

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