Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System

The Dmrt genes encode the transcription factor containing the DM (doublesex and mab-3) domain, an intertwined zinc finger-like DNA binding module. While Dmrt genes are mainly involved in the sexual development of various species, recent studies have revealed that Dmrt genes, which belong to the Dmrt...

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Detalles Bibliográficos
Autores principales: Kikkawa, Takako, Osumi, Noriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695973/
https://www.ncbi.nlm.nih.gov/pubmed/34955736
http://dx.doi.org/10.3389/fnins.2021.789583
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author Kikkawa, Takako
Osumi, Noriko
author_facet Kikkawa, Takako
Osumi, Noriko
author_sort Kikkawa, Takako
collection PubMed
description The Dmrt genes encode the transcription factor containing the DM (doublesex and mab-3) domain, an intertwined zinc finger-like DNA binding module. While Dmrt genes are mainly involved in the sexual development of various species, recent studies have revealed that Dmrt genes, which belong to the DmrtA subfamily, are differentially expressed in the embryonic brain and spinal cord and are essential for the development of the central nervous system. Herein, we summarize recent studies that reveal the multiple functions of the Dmrt genes in various aspects of vertebrate neural development, including brain patterning, neurogenesis, and the specification of neurons.
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spelling pubmed-86959732021-12-24 Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System Kikkawa, Takako Osumi, Noriko Front Neurosci Neuroscience The Dmrt genes encode the transcription factor containing the DM (doublesex and mab-3) domain, an intertwined zinc finger-like DNA binding module. While Dmrt genes are mainly involved in the sexual development of various species, recent studies have revealed that Dmrt genes, which belong to the DmrtA subfamily, are differentially expressed in the embryonic brain and spinal cord and are essential for the development of the central nervous system. Herein, we summarize recent studies that reveal the multiple functions of the Dmrt genes in various aspects of vertebrate neural development, including brain patterning, neurogenesis, and the specification of neurons. Frontiers Media S.A. 2021-12-09 /pmc/articles/PMC8695973/ /pubmed/34955736 http://dx.doi.org/10.3389/fnins.2021.789583 Text en Copyright © 2021 Kikkawa and Osumi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kikkawa, Takako
Osumi, Noriko
Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System
title Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System
title_full Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System
title_fullStr Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System
title_full_unstemmed Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System
title_short Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System
title_sort multiple functions of the dmrt genes in the development of the central nervous system
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695973/
https://www.ncbi.nlm.nih.gov/pubmed/34955736
http://dx.doi.org/10.3389/fnins.2021.789583
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