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Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice

C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of the AP. An in-depth analysis of FH-related protein dimerised minimal (mini)-FH constructs has recently been published...

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Detalles Bibliográficos
Autores principales:	Kamala, Ola, Malik, Talat H., Hallam, Thomas M., Cox, Thomas E., Yang, Yi, Vyas, Falguni, Luli, Saimir, Connelly, Chloe, Gibson, Beth, Smith-Jackson, Kate, Denton, Harriet, Pappworth, Isabel Y., Huang, Lei, Kavanagh, David, Pickering, Matthew C., Marchbank, Kevin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696033/ https://www.ncbi.nlm.nih.gov/pubmed/34956184 http://dx.doi.org/10.3389/fimmu.2021.752916

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