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Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies
PURPOSE: The accurate detection and quantification of hepatic steatosis using a noninvasive method are important for the management of nonalcoholic fatty liver disease. We performed a systematic review and meta-analysis of the accuracy of the ultrasound-measured attenuation coefficient (AC) in the e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Ultrasound in Medicine
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696131/ https://www.ncbi.nlm.nih.gov/pubmed/34399043 http://dx.doi.org/10.14366/usg.21076 |
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author | Jang, Jong Keon Choi, Sang Hyun Lee, Ji Sung Kim, So Yeon Lee, Seung Soo Kim, Kyung Won |
author_facet | Jang, Jong Keon Choi, Sang Hyun Lee, Ji Sung Kim, So Yeon Lee, Seung Soo Kim, Kyung Won |
author_sort | Jang, Jong Keon |
collection | PubMed |
description | PURPOSE: The accurate detection and quantification of hepatic steatosis using a noninvasive method are important for the management of nonalcoholic fatty liver disease. We performed a systematic review and meta-analysis of the accuracy of the ultrasound-measured attenuation coefficient (AC) in the evaluation of hepatic steatosis. METHODS: The PubMed, Embase, and Cochrane databases were searched for prospective studies reporting the diagnostic accuracy of AC for assessing hepatic steatosis. The meta-analytic pooled sensitivity and specificity of AC for any grade of steatosis (S≥1) and advanced steatosis (S≥2) were estimated using a bivariate random-effects model. Meta-regression analysis was conducted to investigate the causes of heterogeneity among studies. RESULTS: Thirteen studies including 1,509 patients were identified. The pooled sensitivity and specificity of AC for S≥1 were 76% (95% confidence interval [CI], 73% to 80%; I(2)=43%) and 84% (95% CI, 77% to 89%; I(2)=74%), respectively, while for S≥2 they were 87% (95% CI, 83% to 91%; I(2)=0%) and 79% (95% CI, 75% to 83%; I(2)=59%), respectively. Study heterogeneity was associated with body mass index (BMI) and the prevalence of steatosis or significant fibrosis. CONCLUSION: AC can be clinically useful for assessing hepatic steatosis, with good overall diagnostic performance. The data reported in the published literature differed according to BMI and the prevalence of steatosis or significant fibrosis, and careful interpretation with consideration of these factors might be needed. |
format | Online Article Text |
id | pubmed-8696131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society of Ultrasound in Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-86961312022-01-06 Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies Jang, Jong Keon Choi, Sang Hyun Lee, Ji Sung Kim, So Yeon Lee, Seung Soo Kim, Kyung Won Ultrasonography Meta-Analysis PURPOSE: The accurate detection and quantification of hepatic steatosis using a noninvasive method are important for the management of nonalcoholic fatty liver disease. We performed a systematic review and meta-analysis of the accuracy of the ultrasound-measured attenuation coefficient (AC) in the evaluation of hepatic steatosis. METHODS: The PubMed, Embase, and Cochrane databases were searched for prospective studies reporting the diagnostic accuracy of AC for assessing hepatic steatosis. The meta-analytic pooled sensitivity and specificity of AC for any grade of steatosis (S≥1) and advanced steatosis (S≥2) were estimated using a bivariate random-effects model. Meta-regression analysis was conducted to investigate the causes of heterogeneity among studies. RESULTS: Thirteen studies including 1,509 patients were identified. The pooled sensitivity and specificity of AC for S≥1 were 76% (95% confidence interval [CI], 73% to 80%; I(2)=43%) and 84% (95% CI, 77% to 89%; I(2)=74%), respectively, while for S≥2 they were 87% (95% CI, 83% to 91%; I(2)=0%) and 79% (95% CI, 75% to 83%; I(2)=59%), respectively. Study heterogeneity was associated with body mass index (BMI) and the prevalence of steatosis or significant fibrosis. CONCLUSION: AC can be clinically useful for assessing hepatic steatosis, with good overall diagnostic performance. The data reported in the published literature differed according to BMI and the prevalence of steatosis or significant fibrosis, and careful interpretation with consideration of these factors might be needed. Korean Society of Ultrasound in Medicine 2022-01 2021-06-01 /pmc/articles/PMC8696131/ /pubmed/34399043 http://dx.doi.org/10.14366/usg.21076 Text en Copyright © 2022 Korean Society of Ultrasound in Medicine (KSUM) https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Meta-Analysis Jang, Jong Keon Choi, Sang Hyun Lee, Ji Sung Kim, So Yeon Lee, Seung Soo Kim, Kyung Won Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies |
title | Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies |
title_full | Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies |
title_fullStr | Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies |
title_full_unstemmed | Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies |
title_short | Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies |
title_sort | accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696131/ https://www.ncbi.nlm.nih.gov/pubmed/34399043 http://dx.doi.org/10.14366/usg.21076 |
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