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Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only currently available curative treatment for sickle cell disease (SCD). However, the effects of HSCT on SCD pathophysiology are poorly elucidated. Here, we assessed red blood cell (RBC) adhesiveness, intensity of hemolysis, vas...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696202/ https://www.ncbi.nlm.nih.gov/pubmed/34956203 http://dx.doi.org/10.3389/fimmu.2021.774442 |
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author | de Azevedo, Júlia Teixeira Cottas Costa, Thalita Cristina de Mello Lima, Keli Cristina Maciel, Thiago Trovati Palma, Patrícia Vianna Bonini Darrigo-Júnior, Luiz Guilherme Setanni Grecco, Carlos Eduardo Stracieri, Ana Beatriz P. L. Elias, Juliana Bernardes Pieroni, Fabiano Guerino-Cunha, Renato Luiz Pinto, Ana Cristina Silva De Santis, Gil Cunha Covas, Dimas Tadeu Hermine, Olivier Simões, Belinda Pinto Oliveira, Maria Carolina Malmegrim, Kelen Cristina Ribeiro |
author_facet | de Azevedo, Júlia Teixeira Cottas Costa, Thalita Cristina de Mello Lima, Keli Cristina Maciel, Thiago Trovati Palma, Patrícia Vianna Bonini Darrigo-Júnior, Luiz Guilherme Setanni Grecco, Carlos Eduardo Stracieri, Ana Beatriz P. L. Elias, Juliana Bernardes Pieroni, Fabiano Guerino-Cunha, Renato Luiz Pinto, Ana Cristina Silva De Santis, Gil Cunha Covas, Dimas Tadeu Hermine, Olivier Simões, Belinda Pinto Oliveira, Maria Carolina Malmegrim, Kelen Cristina Ribeiro |
author_sort | de Azevedo, Júlia Teixeira Cottas |
collection | PubMed |
description | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only currently available curative treatment for sickle cell disease (SCD). However, the effects of HSCT on SCD pathophysiology are poorly elucidated. Here, we assessed red blood cell (RBC) adhesiveness, intensity of hemolysis, vascular tone markers and systemic inflammation, in SCD patients treated with allogeneic HSCT. Thirty-two SCD patients were evaluated before and on long-term follow-up after HSCT. Overall survival was 94% with no severe (grade III-IV) graft-vs-host disease and a 22% rejection rate (graft failure). Hematological parameters, reticulocyte counts, and levels of lactate dehydrogenase (LDH), endothelin-1 and VCAM-1 normalized in SCD patients post-HSCT. Expression of adhesion molecules on reticulocytes and RBC was lower in patients with sustained engraftment. Levels of IL-18, IL-15 and LDH were higher in patients that developed graft failure. Increased levels of plasma pro-inflammatory cytokines, mainly TNF-α, were found in SCD patients long-term after transplantation. SCD patients with sustained engraftment after allo-HSCT showed decreased reticulocyte counts and adhesiveness, diminished hemolysis, and lower levels of vascular tonus markers. Nevertheless, systemic inflammation persists for at least five years after transplantation, indicating that allo-HSCT does not equally affect all aspects of SCD pathophysiology. |
format | Online Article Text |
id | pubmed-8696202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86962022021-12-24 Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients de Azevedo, Júlia Teixeira Cottas Costa, Thalita Cristina de Mello Lima, Keli Cristina Maciel, Thiago Trovati Palma, Patrícia Vianna Bonini Darrigo-Júnior, Luiz Guilherme Setanni Grecco, Carlos Eduardo Stracieri, Ana Beatriz P. L. Elias, Juliana Bernardes Pieroni, Fabiano Guerino-Cunha, Renato Luiz Pinto, Ana Cristina Silva De Santis, Gil Cunha Covas, Dimas Tadeu Hermine, Olivier Simões, Belinda Pinto Oliveira, Maria Carolina Malmegrim, Kelen Cristina Ribeiro Front Immunol Immunology Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only currently available curative treatment for sickle cell disease (SCD). However, the effects of HSCT on SCD pathophysiology are poorly elucidated. Here, we assessed red blood cell (RBC) adhesiveness, intensity of hemolysis, vascular tone markers and systemic inflammation, in SCD patients treated with allogeneic HSCT. Thirty-two SCD patients were evaluated before and on long-term follow-up after HSCT. Overall survival was 94% with no severe (grade III-IV) graft-vs-host disease and a 22% rejection rate (graft failure). Hematological parameters, reticulocyte counts, and levels of lactate dehydrogenase (LDH), endothelin-1 and VCAM-1 normalized in SCD patients post-HSCT. Expression of adhesion molecules on reticulocytes and RBC was lower in patients with sustained engraftment. Levels of IL-18, IL-15 and LDH were higher in patients that developed graft failure. Increased levels of plasma pro-inflammatory cytokines, mainly TNF-α, were found in SCD patients long-term after transplantation. SCD patients with sustained engraftment after allo-HSCT showed decreased reticulocyte counts and adhesiveness, diminished hemolysis, and lower levels of vascular tonus markers. Nevertheless, systemic inflammation persists for at least five years after transplantation, indicating that allo-HSCT does not equally affect all aspects of SCD pathophysiology. Frontiers Media S.A. 2021-12-09 /pmc/articles/PMC8696202/ /pubmed/34956203 http://dx.doi.org/10.3389/fimmu.2021.774442 Text en Copyright © 2021 de Azevedo, Costa, Lima, Maciel, Palma, Darrigo-Júnior, Setanni Grecco, Stracieri, Elias, Pieroni, Guerino-Cunha, Pinto, De Santis, Covas, Hermine, Simões, Oliveira and Malmegrim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology de Azevedo, Júlia Teixeira Cottas Costa, Thalita Cristina de Mello Lima, Keli Cristina Maciel, Thiago Trovati Palma, Patrícia Vianna Bonini Darrigo-Júnior, Luiz Guilherme Setanni Grecco, Carlos Eduardo Stracieri, Ana Beatriz P. L. Elias, Juliana Bernardes Pieroni, Fabiano Guerino-Cunha, Renato Luiz Pinto, Ana Cristina Silva De Santis, Gil Cunha Covas, Dimas Tadeu Hermine, Olivier Simões, Belinda Pinto Oliveira, Maria Carolina Malmegrim, Kelen Cristina Ribeiro Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients |
title | Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients |
title_full | Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients |
title_fullStr | Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients |
title_full_unstemmed | Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients |
title_short | Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients |
title_sort | long-term effects of allogeneic hematopoietic stem cell transplantation on systemic inflammation in sickle cell disease patients |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696202/ https://www.ncbi.nlm.nih.gov/pubmed/34956203 http://dx.doi.org/10.3389/fimmu.2021.774442 |
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