P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer

BACKGROUND: Fascin is crucial for cancer cell filopodium formation and tumor metastasis, and is functionally regulated by post‐translational modifications. However, whether and how Fascin is regulated by acetylation remains unclear. This study explored the regulation of Fascin acetylation and its co...

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Detalles Bibliográficos
Autores principales: Cheng, Yin‐Wei, Zeng, Fa‐Min, Li, Da‐Jia, Wang, Shao‐Hong, He, Jian‐Zhong, Guo, Zhen‐Chang, Nie, Ping‐Juan, Wu, Zhi‐Yong, Shi, Wen‐Qi, Wen, Bing, Xu, Xiu‐E, Liao, Lian‐Di, Li, Zhi‐Mao, Wu, Jian‐Yi, Zhan, Jun, Zhang, Hong‐Quan, Chang, Zhi‐Jie, Zhang, Kai, Xu, Li‐Yan, Li, En‐Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696220/
https://www.ncbi.nlm.nih.gov/pubmed/34555274
http://dx.doi.org/10.1002/cac2.12221

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