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The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool

Missense mutations in the cardiac ryanodine receptor type 2 (RyR2) characteristically cause catecholaminergic arrhythmias. Reminiscent of the phenotype in patients, RyR2-R2474S knockin mice develop exercise-induced ventricular tachyarrhythmias. In cardiomyocytes, increased mitochondrial matrix Ca(2+...

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Detalles Bibliográficos
Autores principales:	Wegener, Jörg W., Wagdi, Ahmed, Wagner, Eva, Katschinski, Dörthe M., Hasenfuss, Gerd, Bruegmann, Tobias, Lehnart, Stephan E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696262/ https://www.ncbi.nlm.nih.gov/pubmed/34955889 http://dx.doi.org/10.3389/fphys.2021.777770

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