Cargando…

Spatio-Semantic Graphs From Picture Description: Applications to Detection of Cognitive Impairment

Clinical assessments often use complex picture description tasks to elicit natural speech patterns and magnify changes occurring in brain regions implicated in Alzheimer's disease and dementia. As The Cookie Theft picture description task is used in the largest Alzheimer's disease and deme...

Descripción completa

Detalles Bibliográficos
Autores principales: Ambadi, Pranav S., Basche, Kristin, Koscik, Rebecca L., Berisha, Visar, Liss, Julie M., Mueller, Kimberly D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696356/
https://www.ncbi.nlm.nih.gov/pubmed/34956070
http://dx.doi.org/10.3389/fneur.2021.795374
_version_ 1784619791918563328
author Ambadi, Pranav S.
Basche, Kristin
Koscik, Rebecca L.
Berisha, Visar
Liss, Julie M.
Mueller, Kimberly D.
author_facet Ambadi, Pranav S.
Basche, Kristin
Koscik, Rebecca L.
Berisha, Visar
Liss, Julie M.
Mueller, Kimberly D.
author_sort Ambadi, Pranav S.
collection PubMed
description Clinical assessments often use complex picture description tasks to elicit natural speech patterns and magnify changes occurring in brain regions implicated in Alzheimer's disease and dementia. As The Cookie Theft picture description task is used in the largest Alzheimer's disease and dementia cohort studies available, we aimed to create algorithms that could characterize the visual narrative path a participant takes in describing what is happening in this image. We proposed spatio-semantic graphs, models based on graph theory that transform the participants' narratives into graphs that retain semantic order and encode the visuospatial information between content units in the image. The resulting graphs differ between Cognitively Impaired and Unimpaired participants in several important ways. Cognitively Impaired participants consistently scored higher on features that are heavily associated with symptoms of cognitive decline, including repetition, evidence of short-term memory lapses, and generally disorganized narrative descriptions, while Cognitively Unimpaired participants produced more efficient narrative paths. These results provide evidence that spatio-semantic graph analysis of these tasks can generate important insights into a participant's cognitive performance that cannot be generated from semantic analysis alone.
format Online
Article
Text
id pubmed-8696356
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86963562021-12-24 Spatio-Semantic Graphs From Picture Description: Applications to Detection of Cognitive Impairment Ambadi, Pranav S. Basche, Kristin Koscik, Rebecca L. Berisha, Visar Liss, Julie M. Mueller, Kimberly D. Front Neurol Neurology Clinical assessments often use complex picture description tasks to elicit natural speech patterns and magnify changes occurring in brain regions implicated in Alzheimer's disease and dementia. As The Cookie Theft picture description task is used in the largest Alzheimer's disease and dementia cohort studies available, we aimed to create algorithms that could characterize the visual narrative path a participant takes in describing what is happening in this image. We proposed spatio-semantic graphs, models based on graph theory that transform the participants' narratives into graphs that retain semantic order and encode the visuospatial information between content units in the image. The resulting graphs differ between Cognitively Impaired and Unimpaired participants in several important ways. Cognitively Impaired participants consistently scored higher on features that are heavily associated with symptoms of cognitive decline, including repetition, evidence of short-term memory lapses, and generally disorganized narrative descriptions, while Cognitively Unimpaired participants produced more efficient narrative paths. These results provide evidence that spatio-semantic graph analysis of these tasks can generate important insights into a participant's cognitive performance that cannot be generated from semantic analysis alone. Frontiers Media S.A. 2021-12-09 /pmc/articles/PMC8696356/ /pubmed/34956070 http://dx.doi.org/10.3389/fneur.2021.795374 Text en Copyright © 2021 Ambadi, Basche, Koscik, Berisha, Liss and Mueller. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Ambadi, Pranav S.
Basche, Kristin
Koscik, Rebecca L.
Berisha, Visar
Liss, Julie M.
Mueller, Kimberly D.
Spatio-Semantic Graphs From Picture Description: Applications to Detection of Cognitive Impairment
title Spatio-Semantic Graphs From Picture Description: Applications to Detection of Cognitive Impairment
title_full Spatio-Semantic Graphs From Picture Description: Applications to Detection of Cognitive Impairment
title_fullStr Spatio-Semantic Graphs From Picture Description: Applications to Detection of Cognitive Impairment
title_full_unstemmed Spatio-Semantic Graphs From Picture Description: Applications to Detection of Cognitive Impairment
title_short Spatio-Semantic Graphs From Picture Description: Applications to Detection of Cognitive Impairment
title_sort spatio-semantic graphs from picture description: applications to detection of cognitive impairment
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696356/
https://www.ncbi.nlm.nih.gov/pubmed/34956070
http://dx.doi.org/10.3389/fneur.2021.795374
work_keys_str_mv AT ambadipranavs spatiosemanticgraphsfrompicturedescriptionapplicationstodetectionofcognitiveimpairment
AT baschekristin spatiosemanticgraphsfrompicturedescriptionapplicationstodetectionofcognitiveimpairment
AT koscikrebeccal spatiosemanticgraphsfrompicturedescriptionapplicationstodetectionofcognitiveimpairment
AT berishavisar spatiosemanticgraphsfrompicturedescriptionapplicationstodetectionofcognitiveimpairment
AT lissjuliem spatiosemanticgraphsfrompicturedescriptionapplicationstodetectionofcognitiveimpairment
AT muellerkimberlyd spatiosemanticgraphsfrompicturedescriptionapplicationstodetectionofcognitiveimpairment