Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2

Severe Acute respiratory syndrome coronavirus (SARS-CoV-1) attaches to the host cell surface to initiate the interaction between the receptor-binding domain (RBD) of its spike glycoprotein (S) and the human Angiotensin-converting enzyme (hACE2) receptor. SARS-CoV-1 mutates frequently because of its...

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Detalles Bibliográficos
Autores principales: Sobitan, Adebiyi, Mahase, Vidhyanand, Rhoades, Raina, Williams, Dejaun, Liu, Dongxiao, Xie, Yixin, Li, Lin, Tang, Qiyi, Teng, Shaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696472/
https://www.ncbi.nlm.nih.gov/pubmed/34957216
http://dx.doi.org/10.3389/fmolb.2021.784303

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