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Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection
Low plasma levels of the signaling lipid metabolite sphingosine 1-phosphate (S1P) are associated with disrupted endothelial cell (EC) barriers, lymphopenia and reduced responsivity to hypoxia. Total S1P levels were also reduced in 23 critically ill patients with coronavirus disease 2019 (COVID-19),...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696489/ https://www.ncbi.nlm.nih.gov/pubmed/34878105 http://dx.doi.org/10.1042/CS20210666 |
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author | Winkler, Martin Sebastian Claus, Ralf Alexander Schilder, Mareike Pöhlmann, Stefan Coldewey, Sina M. Grundmann, Julian Fricke, Torben Moerer, Onnen Meissner, Konrad Bauer, Michael Hofmann-Winkler, Heike Gräler, Markus H. |
author_facet | Winkler, Martin Sebastian Claus, Ralf Alexander Schilder, Mareike Pöhlmann, Stefan Coldewey, Sina M. Grundmann, Julian Fricke, Torben Moerer, Onnen Meissner, Konrad Bauer, Michael Hofmann-Winkler, Heike Gräler, Markus H. |
author_sort | Winkler, Martin Sebastian |
collection | PubMed |
description | Low plasma levels of the signaling lipid metabolite sphingosine 1-phosphate (S1P) are associated with disrupted endothelial cell (EC) barriers, lymphopenia and reduced responsivity to hypoxia. Total S1P levels were also reduced in 23 critically ill patients with coronavirus disease 2019 (COVID-19), and the two main S1P carriers, serum albumin (SA) and high-density lipoprotein (HDL) were dramatically low. Surprisingly, we observed a carrier-changing shift from SA to HDL, which probably prevented an even further drop in S1P levels. Furthermore, intracellular S1P levels in red blood cells (RBCs) were significantly increased in COVID-19 patients compared with healthy controls due to up-regulation of S1P producing sphingosine kinase 1 and down-regulation of S1P degrading lyase expression. Cell culture experiments supported increased sphingosine kinase activity and unchanged S1P release from RBC stores of COVID-19 patients. These observations suggest adaptive mechanisms for maintenance of the vasculature and immunity as well as prevention of tissue hypoxia in COVID-19 patients. |
format | Online Article Text |
id | pubmed-8696489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86964892022-01-05 Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection Winkler, Martin Sebastian Claus, Ralf Alexander Schilder, Mareike Pöhlmann, Stefan Coldewey, Sina M. Grundmann, Julian Fricke, Torben Moerer, Onnen Meissner, Konrad Bauer, Michael Hofmann-Winkler, Heike Gräler, Markus H. Clin Sci (Lond) Immunology & Inflammation Low plasma levels of the signaling lipid metabolite sphingosine 1-phosphate (S1P) are associated with disrupted endothelial cell (EC) barriers, lymphopenia and reduced responsivity to hypoxia. Total S1P levels were also reduced in 23 critically ill patients with coronavirus disease 2019 (COVID-19), and the two main S1P carriers, serum albumin (SA) and high-density lipoprotein (HDL) were dramatically low. Surprisingly, we observed a carrier-changing shift from SA to HDL, which probably prevented an even further drop in S1P levels. Furthermore, intracellular S1P levels in red blood cells (RBCs) were significantly increased in COVID-19 patients compared with healthy controls due to up-regulation of S1P producing sphingosine kinase 1 and down-regulation of S1P degrading lyase expression. Cell culture experiments supported increased sphingosine kinase activity and unchanged S1P release from RBC stores of COVID-19 patients. These observations suggest adaptive mechanisms for maintenance of the vasculature and immunity as well as prevention of tissue hypoxia in COVID-19 patients. Portland Press Ltd. 2021-12 2021-12-22 /pmc/articles/PMC8696489/ /pubmed/34878105 http://dx.doi.org/10.1042/CS20210666 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Immunology & Inflammation Winkler, Martin Sebastian Claus, Ralf Alexander Schilder, Mareike Pöhlmann, Stefan Coldewey, Sina M. Grundmann, Julian Fricke, Torben Moerer, Onnen Meissner, Konrad Bauer, Michael Hofmann-Winkler, Heike Gräler, Markus H. Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection |
title | Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection |
title_full | Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection |
title_fullStr | Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection |
title_full_unstemmed | Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection |
title_short | Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection |
title_sort | erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to sars-cov-2 infection |
topic | Immunology & Inflammation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696489/ https://www.ncbi.nlm.nih.gov/pubmed/34878105 http://dx.doi.org/10.1042/CS20210666 |
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