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N-Alkylation/aldol reaction of α-aldimino thioesters: a facile three-component coupling reaction

Theoretical calculation of the reactivity of α-imino thioesters indicates that they are very reactive substrates for Umpolung N-alkylation. In fact, treatment of α-aldimino thioesters with dialkylzinc reagents in the presence of aldehydes or imines gives three-component coupling products in good yie...

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Detalles Bibliográficos
Autores principales: Shimizu, Makoto, Higashino, Asako, Mizota, Isao, Zhu, Yusong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697212/
https://www.ncbi.nlm.nih.gov/pubmed/35423863
http://dx.doi.org/10.1039/d1ra02000e