Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols

Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily available o-nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including alcohol oxidation, nitro reduction, condensa...

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Autores principales: Wang, Ke, Chen, Hao, Dai, Xinyan, Huang, Xupeng, Feng, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697358/
https://www.ncbi.nlm.nih.gov/pubmed/35423854
http://dx.doi.org/10.1039/d1ra01755a
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author Wang, Ke
Chen, Hao
Dai, Xinyan
Huang, Xupeng
Feng, Zhiqiang
author_facet Wang, Ke
Chen, Hao
Dai, Xinyan
Huang, Xupeng
Feng, Zhiqiang
author_sort Wang, Ke
collection PubMed
description Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily available o-nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including alcohol oxidation, nitro reduction, condensation, and dehydrogenation occurs without any added reducing or oxidizing agent.
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spelling pubmed-86973582022-04-13 Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols Wang, Ke Chen, Hao Dai, Xinyan Huang, Xupeng Feng, Zhiqiang RSC Adv Chemistry Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily available o-nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including alcohol oxidation, nitro reduction, condensation, and dehydrogenation occurs without any added reducing or oxidizing agent. The Royal Society of Chemistry 2021-04-07 /pmc/articles/PMC8697358/ /pubmed/35423854 http://dx.doi.org/10.1039/d1ra01755a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wang, Ke
Chen, Hao
Dai, Xinyan
Huang, Xupeng
Feng, Zhiqiang
Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols
title Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols
title_full Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols
title_fullStr Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols
title_full_unstemmed Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols
title_short Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols
title_sort palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3h)-ones from o-nitrobenzamide and alcohols
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697358/
https://www.ncbi.nlm.nih.gov/pubmed/35423854
http://dx.doi.org/10.1039/d1ra01755a
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AT daixinyan palladiumcatalyzedonepotsynthesisof2substitutedquinazolin43honesfromonitrobenzamideandalcohols
AT huangxupeng palladiumcatalyzedonepotsynthesisof2substitutedquinazolin43honesfromonitrobenzamideandalcohols
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