Cargando…
Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases
OBJECTIVES: To investigate whether physical activity is associated with enhanced immunogenicity of a SARS-CoV-2 inactivated vaccine (Coronavac) in patients with autoimmune rheumatic diseases (ARD) (n = 898) and in non-ARD (n = 197) individuals without pre-existing immunogenicity to SARS-CoV-2. METHO...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697420/ https://www.ncbi.nlm.nih.gov/pubmed/34954325 http://dx.doi.org/10.1016/j.bbi.2021.12.016 |
_version_ | 1784620043115429888 |
---|---|
author | Gualano, Bruno Lemes, Italo R. Silva, Rafael P. Pinto, Ana J. Mazzolani, Bruna C. Smaira, Fabiana I. Sieczkowska, Sofia M. Aikawa, Nadia E. Pasoto, Sandra G. Medeiros-Ribeiro, Ana C. Saad, Carla G.S. Yuki, Emily F.N. Silva, Clovis A. Swinton, Paul Hallal, Pedro C. Roschel, Hamilton Bonfa, Eloisa |
author_facet | Gualano, Bruno Lemes, Italo R. Silva, Rafael P. Pinto, Ana J. Mazzolani, Bruna C. Smaira, Fabiana I. Sieczkowska, Sofia M. Aikawa, Nadia E. Pasoto, Sandra G. Medeiros-Ribeiro, Ana C. Saad, Carla G.S. Yuki, Emily F.N. Silva, Clovis A. Swinton, Paul Hallal, Pedro C. Roschel, Hamilton Bonfa, Eloisa |
author_sort | Gualano, Bruno |
collection | PubMed |
description | OBJECTIVES: To investigate whether physical activity is associated with enhanced immunogenicity of a SARS-CoV-2 inactivated vaccine (Coronavac) in patients with autoimmune rheumatic diseases (ARD) (n = 898) and in non-ARD (n = 197) individuals without pre-existing immunogenicity to SARS-CoV-2. METHODS: This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial. Immunogenicity was assessed after vaccination by measuring seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG (SC), geometric mean titers of anti-S1/S2 IgG (GMT), factor-increase in GMT (FI-GMT), frequency of neutralizing antibody (NAb), and median neutralizing activity. Physical activity (active being defined as ≥ 150 min/week) and sedentary behavior (>8h/day) were assessed by questionnaire. RESULTS: Physically active ARD patients (n = 494) were younger and less frequently used prednisone/biologics than inactive patients (n = 404). After controlling for covariates, active patients exhibited greater SC (OR: 1.4 [95%CI: 1.1–2.0]), GMT (32% [95%CI: 8.8–60) and FI-GMT (33% [95%CI: 9.6–63%]) vs. inactive. Cluster analysis (physical activity/sedentary status) revealed greater GMT (43.0% [95% CI: 11.0–84.0%) and FI-GMT (48.0% [95%CI: 14.0–92.0%]) in active/non-sedentary vs. inactive/sedentary ARD patients. A dose–response was observed, with greater benefits for the group of patients performing ≥ 350 min/week of physical activity (OR: 1.6 [95%CI: 1.1–2.4]; 41% [95%CI: 10–80%]; 35% [95%CI: 4.3–74], for SC, GMT, and FI-GMT, respectively) vs. the least active group (≤30 min/week). Greater SC (OR: 9.9 [95%CI: 1.1–89.0]) and GMT (26% [95%CI: 2.2–56.0%]) were observed in active vs. inactive non-ARD. CONCLUSIONS: A physically active lifestyle may enhance SARS-CoV-2 vaccine immunogenicity, a finding of particular clinical relevance for immunocompromised patients. TRIAL REGISTRATION: Clinicaltrials.gov #NCT04754698. |
format | Online Article Text |
id | pubmed-8697420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86974202021-12-23 Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases Gualano, Bruno Lemes, Italo R. Silva, Rafael P. Pinto, Ana J. Mazzolani, Bruna C. Smaira, Fabiana I. Sieczkowska, Sofia M. Aikawa, Nadia E. Pasoto, Sandra G. Medeiros-Ribeiro, Ana C. Saad, Carla G.S. Yuki, Emily F.N. Silva, Clovis A. Swinton, Paul Hallal, Pedro C. Roschel, Hamilton Bonfa, Eloisa Brain Behav Immun Article OBJECTIVES: To investigate whether physical activity is associated with enhanced immunogenicity of a SARS-CoV-2 inactivated vaccine (Coronavac) in patients with autoimmune rheumatic diseases (ARD) (n = 898) and in non-ARD (n = 197) individuals without pre-existing immunogenicity to SARS-CoV-2. METHODS: This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial. Immunogenicity was assessed after vaccination by measuring seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG (SC), geometric mean titers of anti-S1/S2 IgG (GMT), factor-increase in GMT (FI-GMT), frequency of neutralizing antibody (NAb), and median neutralizing activity. Physical activity (active being defined as ≥ 150 min/week) and sedentary behavior (>8h/day) were assessed by questionnaire. RESULTS: Physically active ARD patients (n = 494) were younger and less frequently used prednisone/biologics than inactive patients (n = 404). After controlling for covariates, active patients exhibited greater SC (OR: 1.4 [95%CI: 1.1–2.0]), GMT (32% [95%CI: 8.8–60) and FI-GMT (33% [95%CI: 9.6–63%]) vs. inactive. Cluster analysis (physical activity/sedentary status) revealed greater GMT (43.0% [95% CI: 11.0–84.0%) and FI-GMT (48.0% [95%CI: 14.0–92.0%]) in active/non-sedentary vs. inactive/sedentary ARD patients. A dose–response was observed, with greater benefits for the group of patients performing ≥ 350 min/week of physical activity (OR: 1.6 [95%CI: 1.1–2.4]; 41% [95%CI: 10–80%]; 35% [95%CI: 4.3–74], for SC, GMT, and FI-GMT, respectively) vs. the least active group (≤30 min/week). Greater SC (OR: 9.9 [95%CI: 1.1–89.0]) and GMT (26% [95%CI: 2.2–56.0%]) were observed in active vs. inactive non-ARD. CONCLUSIONS: A physically active lifestyle may enhance SARS-CoV-2 vaccine immunogenicity, a finding of particular clinical relevance for immunocompromised patients. TRIAL REGISTRATION: Clinicaltrials.gov #NCT04754698. Elsevier Inc. 2022-03 2021-12-23 /pmc/articles/PMC8697420/ /pubmed/34954325 http://dx.doi.org/10.1016/j.bbi.2021.12.016 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Gualano, Bruno Lemes, Italo R. Silva, Rafael P. Pinto, Ana J. Mazzolani, Bruna C. Smaira, Fabiana I. Sieczkowska, Sofia M. Aikawa, Nadia E. Pasoto, Sandra G. Medeiros-Ribeiro, Ana C. Saad, Carla G.S. Yuki, Emily F.N. Silva, Clovis A. Swinton, Paul Hallal, Pedro C. Roschel, Hamilton Bonfa, Eloisa Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases |
title | Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases |
title_full | Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases |
title_fullStr | Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases |
title_full_unstemmed | Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases |
title_short | Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases |
title_sort | association between physical activity and immunogenicity of an inactivated virus vaccine against sars-cov-2 in patients with autoimmune rheumatic diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697420/ https://www.ncbi.nlm.nih.gov/pubmed/34954325 http://dx.doi.org/10.1016/j.bbi.2021.12.016 |
work_keys_str_mv | AT gualanobruno associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT lemesitalor associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT silvarafaelp associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT pintoanaj associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT mazzolanibrunac associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT smairafabianai associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT sieczkowskasofiam associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT aikawanadiae associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT pasotosandrag associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT medeirosribeiroanac associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT saadcarlags associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT yukiemilyfn associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT silvaclovisa associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT swintonpaul associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT hallalpedroc associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT roschelhamilton associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases AT bonfaeloisa associationbetweenphysicalactivityandimmunogenicityofaninactivatedvirusvaccineagainstsarscov2inpatientswithautoimmunerheumaticdiseases |