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Evolution of Optimized Hydride Transfer Reaction and Overall Enzyme Turnover in Human Dihydrofolate Reductase

[Image: see text] Evolution of dihydrofolate reductase (DHFR) has been studied using the enzyme from Escherichia coli DHFR (ecDHFR) as a model, but less studies have used the enzyme from Homo sapiens DHFR (hsDHFR). Each enzyme maintains a short and narrow distribution of hydride donor-acceptor dista...

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Detalles Bibliográficos
Autores principales:	Li, Jiayue, Lin, Jennifer, Kohen, Amnon, Singh, Priyanka, Francis, Kevin, Cheatum, Christopher M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697555/ https://www.ncbi.nlm.nih.gov/pubmed/34875176 http://dx.doi.org/10.1021/acs.biochem.1c00558

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