Cargando…

Evolution of Optimized Hydride Transfer Reaction and Overall Enzyme Turnover in Human Dihydrofolate Reductase

[Image: see text] Evolution of dihydrofolate reductase (DHFR) has been studied using the enzyme from Escherichia coli DHFR (ecDHFR) as a model, but less studies have used the enzyme from Homo sapiens DHFR (hsDHFR). Each enzyme maintains a short and narrow distribution of hydride donor-acceptor dista...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jiayue, Lin, Jennifer, Kohen, Amnon, Singh, Priyanka, Francis, Kevin, Cheatum, Christopher M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697555/ https://www.ncbi.nlm.nih.gov/pubmed/34875176 http://dx.doi.org/10.1021/acs.biochem.1c00558

Ejemplares similares

Extension and Limits of the Network of Coupled Motions Correlated to Hydride Transfer in Dihydrofolate Reductase
por: Singh, Priyanka, et al.
Publicado: (2014)

Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis
por: Kohen, Amnon
Publicado: (2015)

A calibration curve for immobilized dihydrofolate reductase activity assay
por: Singh, Priyanka, et al.
Publicado: (2015)

Loss of Hyperconjugative Effects Drives Hydride Transfer during Dihydrofolate Reductase Catalysis
por: Angelastro, Antonio, et al.
Publicado: (2019)

Protein Mass-Modulated Effects in the Catalytic Mechanism of Dihydrofolate Reductase: Beyond Promoting Vibrations
por: Wang, Zhen, et al.
Publicado: (2014)

Evolution Alters the Enzymatic Reaction Coordinate of Dihydrofolate Reductase
por: Masterson, Jean E., et al.
Publicado: (2014)

Multiple Reaction Pathways in the Morphinone Reductase-Catalyzed Hydride Transfer Reaction
por: Chen, Xi, et al.
Publicado: (2020)

Minimization of dynamic effects in the evolution of dihydrofolate reductase
por: Ruiz-Pernía, J. Javier, et al.
Publicado: (2016)

Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase
por: Duff, Michael R., et al.
Publicado: (2015)

Divergent evolution of protein conformational dynamics in dihydrofolate reductase
por: Bhabha, Gira, et al.
Publicado: (2013)

Isotope Effects as Probes for Enzyme Catalyzed Hydrogen-Transfer Reactions
por: Roston, Daniel, et al.
Publicado: (2013)

Adaptations for Pressure and Temperature in Dihydrofolate Reductases
por: Penhallurick, Ryan W., et al.
Publicado: (2021)

Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan
por: Bilsland, Elizabeth, et al.
Publicado: (2018)

Why Are Some Enzymes Dimers? Flexibility and Catalysis in Thermotoga maritima Dihydrofolate Reductase
por: Ruiz-Pernía, J. Javier, et al.
Publicado: (2019)

Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum
por: Costanzo, Marna S., et al.
Publicado: (2011)

Comparative Hydrogen–Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 °C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein
por: Oyeyemi, Olayinka A., et al.
Publicado: (2011)

Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer
por: Singh, Amrinder, et al.
Publicado: (2018)

Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors
por: Wróbel, Agnieszka, et al.
Publicado: (2019)

The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase
por: Heppler, Lisa N., et al.
Publicado: (2021)

Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase
por: Sánchez-del-Campo, Luís, et al.
Publicado: (2009)

The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase
por: Loveridge, E. Joel, et al.
Publicado: (2011)

Side Chain Conformational Averaging in Human Dihydrofolate Reductase
por: Tuttle, Lisa M., et al.
Publicado: (2014)

Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases
por: Luk, Louis Y. P., et al.
Publicado: (2014)

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

Linking Protein Motion to Enzyme Catalysis
por: Singh, Priyanka, et al.
Publicado: (2015)

Dihydrofolate Reductase Gene Variations in Susceptibility to Disease and Treatment Outcomes
por: Askari, Bahram S., et al.
Publicado: (2010)

Lausannevirus Encodes a Functional Dihydrofolate Reductase Susceptible to Proguanil
por: Mueller, L., et al.
Publicado: (2017)

Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese
por: Xu, Guodong, et al.
Publicado: (2020)

Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase
por: Wang, Yinghui, et al.
Publicado: (2021)

Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase
por: Silva, Pedro J.
Publicado: (2022)

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
por: Shanks, Emma J., et al.
Publicado: (2010)

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase
por: Tassone, Giusy, et al.
Publicado: (2021)

Mechanistic basis for tuning iridium hydride photochemistry from H(2) evolution to hydride transfer hydrodechlorination
por: Barrett, Seth M., et al.
Publicado: (2020)

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
por: Hawkins, Vivian N, et al.
Publicado: (2008)

Dihydrofolate Reductase I164L Mutation in Plasmodium falciparum, Madagascar
por: Ménard, Didier, et al.
Publicado: (2008)

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
por: Choowongkomon, Kiattawee, et al.
Publicado: (2010)

Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus
por: Guo, Jiannan, et al.
Publicado: (2014)

Molecular Docking Analysis of Pyrimethamine Derivatives with Plasmodium falciparum Dihydrofolate Reductase
por: Singh, Indra Vikram, et al.
Publicado: (2018)

Molecular Characteristics and Serodiagnostic Potential of Dihydrofolate Reductase from Echinococcus granulosus
por: Song, Xingju, et al.
Publicado: (2017)

A comparative molecular docking study of curcumin and methotrexate to dihydrofolate reductase
por: Hobani, Yahya, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kglk2cqabmo849j9ifqt1ou6cb