Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report

This is the first autopsy report of hepatotoxicity from nivolumab immunotherapy for malignant mesothelioma. The increase in levels of biliary enzymes and randomly distributed endothelial damage were steroid‐refractory, but second‐line option was abandoned because of cachexia. Further discussions are...

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Autores principales: Arai, Kazumori, Matsuda, Masanori, Nakayasu, Hiromasa, Meguro, Shiori, Kurokami, Takafumi, Kubota, Aki, Iwasaki, Tomohiro, Suzuki, Makoto, Kawaguchi, Shinya, Iwashita, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697699/
https://www.ncbi.nlm.nih.gov/pubmed/34987810
http://dx.doi.org/10.1002/ccr3.5174
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author Arai, Kazumori
Matsuda, Masanori
Nakayasu, Hiromasa
Meguro, Shiori
Kurokami, Takafumi
Kubota, Aki
Iwasaki, Tomohiro
Suzuki, Makoto
Kawaguchi, Shinya
Iwashita, Toshihide
author_facet Arai, Kazumori
Matsuda, Masanori
Nakayasu, Hiromasa
Meguro, Shiori
Kurokami, Takafumi
Kubota, Aki
Iwasaki, Tomohiro
Suzuki, Makoto
Kawaguchi, Shinya
Iwashita, Toshihide
author_sort Arai, Kazumori
collection PubMed
description This is the first autopsy report of hepatotoxicity from nivolumab immunotherapy for malignant mesothelioma. The increase in levels of biliary enzymes and randomly distributed endothelial damage were steroid‐refractory, but second‐line option was abandoned because of cachexia. Further discussions are needed regarding the customized management of immune‐related toxicities.
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spelling pubmed-86976992022-01-04 Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report Arai, Kazumori Matsuda, Masanori Nakayasu, Hiromasa Meguro, Shiori Kurokami, Takafumi Kubota, Aki Iwasaki, Tomohiro Suzuki, Makoto Kawaguchi, Shinya Iwashita, Toshihide Clin Case Rep Case Report This is the first autopsy report of hepatotoxicity from nivolumab immunotherapy for malignant mesothelioma. The increase in levels of biliary enzymes and randomly distributed endothelial damage were steroid‐refractory, but second‐line option was abandoned because of cachexia. Further discussions are needed regarding the customized management of immune‐related toxicities. John Wiley and Sons Inc. 2021-12-23 /pmc/articles/PMC8697699/ /pubmed/34987810 http://dx.doi.org/10.1002/ccr3.5174 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Arai, Kazumori
Matsuda, Masanori
Nakayasu, Hiromasa
Meguro, Shiori
Kurokami, Takafumi
Kubota, Aki
Iwasaki, Tomohiro
Suzuki, Makoto
Kawaguchi, Shinya
Iwashita, Toshihide
Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report
title Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report
title_full Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report
title_fullStr Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report
title_full_unstemmed Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report
title_short Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report
title_sort nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: an autopsy case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697699/
https://www.ncbi.nlm.nih.gov/pubmed/34987810
http://dx.doi.org/10.1002/ccr3.5174
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