Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism.

Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote distal metastasis. Here, we analyzed the involvement of melanoma-secreted EVs in lymph node pre-metastatic niche formation in murine models. We found that small EVs (sEVs) derived from metastatic melanoma cell lin...

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Detalles Bibliográficos
Autores principales: García-Silva, Susana, Benito-Martín, Alberto, Nogués, Laura, Hernández-Barranco, Alberto, Mazariegos, Marina S., Santos, Vanesa, Hergueta-Redondo, Marta, Ximénez-Embún, Pilar, Kataru, Raghu P., Lopez, Ana Amor, Merino, Cristina, Sánchez-Redondo, Sara, Graña-Castro, Osvaldo, Matei, Irina, Nicolás-Avila, José Ángel, Torres-Ruiz, Raúl, Rodríguez-Perales, Sandra, Martínez, Lola, Pérez-Martínez, Manuel, Mata, Gadea, Szumera-Ciećkiewicz, Anna, Kalinowska, Iwona, Saltari, Annalisa, Martínez-Gómez, Julia M., Hogan, Sabrina A., Saragovi, H. Uri, Ortega, Sagrario, Garcia-Martin, Carmen, Boskovic, Jasminka, Levesque, Mitchell P., Rutkowski, Piotr, Hidalgo, Andrés, Muñoz, Javier, Megías, Diego, Mehrara, Babak J., Lyden, David, Peinado, Héctor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697753/
https://www.ncbi.nlm.nih.gov/pubmed/34957415
http://dx.doi.org/10.1038/s43018-021-00272-y

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