Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating

SARS-CoV-2 infects cardiac cells and causes heart dysfunction. Conditions such as myocarditis and arrhythmia have been reported in COVID-19 patients. The Sigma-1 receptor (S1R) is a ubiquitously expressed chaperone that plays a central role in cardiomyocyte function. S1R has been proposed as a thera...

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Detalles Bibliográficos
Autores principales: Salerno, José Alexandre, Torquato, Thayana, Temerozo, Jairo R., Goto-Silva, Livia, Karmirian, Karina, Mendes, Mayara A., Sacramento, Carolina Q., Fintelman-Rodrigues, Natalia, Souza, Letícia R Q., Ornelas, Isis M., Veríssimo, Carla P., Aragão, Luiz Guilherme H S., Vitória, Gabriela, Pedrosa, Carolina S G., da Silva Gomes Dias, Suelen, Cardoso Soares, Vinicius, Puig-Pijuan, Teresa, Salazar, Vinícius, Dariolli, Rafael, Biagi, Diogo, Furtado, Daniel R., Barreto Chiarini, Luciana, Borges, Helena L., Bozza, Patrícia T., Zaluar P. Guimarães, Marilia, Souza, Thiago M.L., Rehen, Stevens K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697769/
https://www.ncbi.nlm.nih.gov/pubmed/35036128
http://dx.doi.org/10.7717/peerj.12595

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