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Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion
Singlet oxygen generated by photosensitization has limited potential in vivo due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cyclorev...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697772/ https://www.ncbi.nlm.nih.gov/pubmed/35423982 http://dx.doi.org/10.1039/d1ra02569d |
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author | Liu, Meina Ucar, Esma Liu, Ziang Wang, Lei Yang, Li Xu, Jiawei Akkaya, Engin U. |
author_facet | Liu, Meina Ucar, Esma Liu, Ziang Wang, Lei Yang, Li Xu, Jiawei Akkaya, Engin U. |
author_sort | Liu, Meina |
collection | PubMed |
description | Singlet oxygen generated by photosensitization has limited potential in vivo due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cycloreversion reaction and the diffusion distance of the excited state molecular oxygen species, is a clear advantage, considering the serious side effects of off-target anticoagulants. In this work, we present novel 1,4-naphthalene endoperoxides as potential anti-coagulant agents due to thermal release of singlet oxygen. |
format | Online Article Text |
id | pubmed-8697772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-86977722022-04-13 Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion Liu, Meina Ucar, Esma Liu, Ziang Wang, Lei Yang, Li Xu, Jiawei Akkaya, Engin U. RSC Adv Chemistry Singlet oxygen generated by photosensitization has limited potential in vivo due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cycloreversion reaction and the diffusion distance of the excited state molecular oxygen species, is a clear advantage, considering the serious side effects of off-target anticoagulants. In this work, we present novel 1,4-naphthalene endoperoxides as potential anti-coagulant agents due to thermal release of singlet oxygen. The Royal Society of Chemistry 2021-04-19 /pmc/articles/PMC8697772/ /pubmed/35423982 http://dx.doi.org/10.1039/d1ra02569d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Liu, Meina Ucar, Esma Liu, Ziang Wang, Lei Yang, Li Xu, Jiawei Akkaya, Engin U. Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion |
title | Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion |
title_full | Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion |
title_fullStr | Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion |
title_full_unstemmed | Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion |
title_short | Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion |
title_sort | anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697772/ https://www.ncbi.nlm.nih.gov/pubmed/35423982 http://dx.doi.org/10.1039/d1ra02569d |
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