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Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion

Singlet oxygen generated by photosensitization has limited potential in vivo due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cyclorev...

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Detalles Bibliográficos
Autores principales: Liu, Meina, Ucar, Esma, Liu, Ziang, Wang, Lei, Yang, Li, Xu, Jiawei, Akkaya, Engin U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697772/
https://www.ncbi.nlm.nih.gov/pubmed/35423982
http://dx.doi.org/10.1039/d1ra02569d
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author Liu, Meina
Ucar, Esma
Liu, Ziang
Wang, Lei
Yang, Li
Xu, Jiawei
Akkaya, Engin U.
author_facet Liu, Meina
Ucar, Esma
Liu, Ziang
Wang, Lei
Yang, Li
Xu, Jiawei
Akkaya, Engin U.
author_sort Liu, Meina
collection PubMed
description Singlet oxygen generated by photosensitization has limited potential in vivo due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cycloreversion reaction and the diffusion distance of the excited state molecular oxygen species, is a clear advantage, considering the serious side effects of off-target anticoagulants. In this work, we present novel 1,4-naphthalene endoperoxides as potential anti-coagulant agents due to thermal release of singlet oxygen.
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spelling pubmed-86977722022-04-13 Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion Liu, Meina Ucar, Esma Liu, Ziang Wang, Lei Yang, Li Xu, Jiawei Akkaya, Engin U. RSC Adv Chemistry Singlet oxygen generated by photosensitization has limited potential in vivo due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cycloreversion reaction and the diffusion distance of the excited state molecular oxygen species, is a clear advantage, considering the serious side effects of off-target anticoagulants. In this work, we present novel 1,4-naphthalene endoperoxides as potential anti-coagulant agents due to thermal release of singlet oxygen. The Royal Society of Chemistry 2021-04-19 /pmc/articles/PMC8697772/ /pubmed/35423982 http://dx.doi.org/10.1039/d1ra02569d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Liu, Meina
Ucar, Esma
Liu, Ziang
Wang, Lei
Yang, Li
Xu, Jiawei
Akkaya, Engin U.
Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion
title Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion
title_full Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion
title_fullStr Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion
title_full_unstemmed Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion
title_short Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion
title_sort anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697772/
https://www.ncbi.nlm.nih.gov/pubmed/35423982
http://dx.doi.org/10.1039/d1ra02569d
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