A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)

The disruption of copper homeostasis (Cu(+)/Cu(2+)) may cause neurodegenerative disorders. Thus, the need for understanding the role of Cu(+) in physiological and pathological processes prompted the development of improved methods of Cu(+) analysis. Herein, a new near-infrared (NIR) fluorescent turn...

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Autores principales: Liu, Yiqing, Kang, Ting, He, Qian, Hu, Yuefu, Zuo, Zeping, Cao, Zhihua, Ke, Bowen, Zhang, Weiyi, Qi, Qingrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697812/
https://www.ncbi.nlm.nih.gov/pubmed/35423960
http://dx.doi.org/10.1039/d1ra00725d
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author Liu, Yiqing
Kang, Ting
He, Qian
Hu, Yuefu
Zuo, Zeping
Cao, Zhihua
Ke, Bowen
Zhang, Weiyi
Qi, Qingrong
author_facet Liu, Yiqing
Kang, Ting
He, Qian
Hu, Yuefu
Zuo, Zeping
Cao, Zhihua
Ke, Bowen
Zhang, Weiyi
Qi, Qingrong
author_sort Liu, Yiqing
collection PubMed
description The disruption of copper homeostasis (Cu(+)/Cu(2+)) may cause neurodegenerative disorders. Thus, the need for understanding the role of Cu(+) in physiological and pathological processes prompted the development of improved methods of Cu(+) analysis. Herein, a new near-infrared (NIR) fluorescent turn-on probe (NPCu) for the detection of Cu(+) was developed based on a Cu(+)-mediated benzylic ether bond cleavage mechanism. The probe showed high selectivity and sensitivity toward Cu(+), and was successfully applied for bioimaging of Cu(+) in living cells.
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spelling pubmed-86978122022-04-13 A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i) Liu, Yiqing Kang, Ting He, Qian Hu, Yuefu Zuo, Zeping Cao, Zhihua Ke, Bowen Zhang, Weiyi Qi, Qingrong RSC Adv Chemistry The disruption of copper homeostasis (Cu(+)/Cu(2+)) may cause neurodegenerative disorders. Thus, the need for understanding the role of Cu(+) in physiological and pathological processes prompted the development of improved methods of Cu(+) analysis. Herein, a new near-infrared (NIR) fluorescent turn-on probe (NPCu) for the detection of Cu(+) was developed based on a Cu(+)-mediated benzylic ether bond cleavage mechanism. The probe showed high selectivity and sensitivity toward Cu(+), and was successfully applied for bioimaging of Cu(+) in living cells. The Royal Society of Chemistry 2021-04-21 /pmc/articles/PMC8697812/ /pubmed/35423960 http://dx.doi.org/10.1039/d1ra00725d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Liu, Yiqing
Kang, Ting
He, Qian
Hu, Yuefu
Zuo, Zeping
Cao, Zhihua
Ke, Bowen
Zhang, Weiyi
Qi, Qingrong
A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)
title A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)
title_full A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)
title_fullStr A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)
title_full_unstemmed A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)
title_short A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)
title_sort selective and sensitive near-infrared fluorescent probe for real-time detection of cu(i)
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697812/
https://www.ncbi.nlm.nih.gov/pubmed/35423960
http://dx.doi.org/10.1039/d1ra00725d
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