Single point mutations can potentially enhance infectivity of SARS-CoV-2 revealed by in silico affinity maturation and SPR assay

The RBD (receptor binding domain) of the SARS-CoV-2 virus S (spike) protein mediates viral cell attachment and serves as a promising target for therapeutics development. Mutations on the S-RBD may alter its affinity to the cell receptor and affect the potency of vaccines and antibodies. Here we used...

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Detalles Bibliográficos
Autores principales: Xue, Ting, Wu, Weikun, Guo, Ning, Wu, Chengyong, Huang, Jian, Lai, Lipeng, Liu, Hong, Li, Yalun, Wang, Tianyuan, Wang, Yuxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697837/
https://www.ncbi.nlm.nih.gov/pubmed/35423963
http://dx.doi.org/10.1039/d1ra00426c

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