Genomics Confirm an Alarming Status of the Genetic Diversity of Belgian Red and Belgian White Red Cattle

SIMPLE SUMMARY: Genetic diversity of livestock is vitally important as it enables the adaptation of future populations to changing environments. Therefore, preserving a sufficiently large genetic diversity is key. However, for many local cattle populations, little is known about their genetic diversity such as inbreeding level, effective size etc. We studied the genetic diversity of two local Belgian red cattle populations (Belgian Red and Belgian White Red cattle) using state-of-the-art genomic techniques. These tools assessed diversity at the population and individual level, and allowed the positioning of these two breeds in an international context of 52 other (European) cattle breeds. Accordingly, we contribute to the general knowledge of European red cattle, and more specifically we help the breeders, breed organization and the government to manage the genetic diversity of both breeds. ABSTRACT: Genetic diversity is increasingly important for researchers and society. Small and local populations deserve more attention especially, as they may harbor important characteristics. Moreover, small populations are at greater risk and their genetic management is often more challenging. Likewise, European red cattle populations are threatened, as they are outcompeted by more specialized cattle breeds. In this study, we investigate the genetic diversity of two local Belgian red cattle breeds: Belgian Red and Belgian White Red cattle. A total of 270 animals were genotyped via medium density SNP arrays. Genetic diversity was assessed using runs of homozygosity screening, effective population size estimation and F(st) analyses. Genomic inbreeding coefficients based on runs of homozygosity were estimated at 7.0% for Belgian Red and 6.1% for Belgian White Red cattle, and both populations had a low effective population size (68 and 86, respectively). PCA, F(st) and admixture analyses revealed the relationship to 52 other international breeds, where they were closest related to some Belgian, French, Scandinavian and Dutch breeds. Moreover, F(st) analyses revealed for Belgian Red cattle a signature of selection on BTA6, adjacent to the KIT gene. This study gains important knowledge on the genetic diversity of these two small local red cattle breeds, and will aid in their (genetic) management.