A Critical Overview on Prostaglandin Inhibitors and Their Influence on Pregnancy Results after Insemination and Embryo Transfer in Cows

SIMPLE SUMMARY: Assisted reproductive techniques, such as artificial insemination or embryo transfer have been used in cattle reproduction for decades, but despite many methodological improvements, pregnancy rates have not increased proportionately. One strategy to improve the pregnancy rate after artificial insemination and embryo transfer is to increase the chance of early embryo survival with the use of medications such as nonsteroidal anti-inflammatory drugs. This paper compares the effect of the application of the most frequently used nonsteroidal anti-inflammatory drugs in cattle (flunixin meglumine, carprofen, meloxicam, ibuprofen, aspirin, and sildenafil), as well as of steroid drugs that are used less frequently in cattle reproduction. An evaluation of published reports revealed a range of outcomes that were not always consistent with each other. However, a positive effect of nonsteroidal anti-inflammatory drug treatment on the pregnancy rate in cattle was indicated, especially with the use of flunixin meglumine. ABSTRACT: Assisted reproductive techniques in cattle, such as artificial insemination (AI) and embryo transfer (ET), are widely used. Despite many years of methodological improvements, the pregnancy rate (PR) in cows has not increased in direct proportion with their development. Among the possibilities to increase the PR is the use of certain steroids and nonsteroidal anti-inflammatory drugs (NSAIDs). The antiluteolytic effect of NSAIDs is achieved by blocking cyclooxygenase, which is involved in the conversion of arachidonic acid to prostaglandins. This article compares the PRs obtained after treatment with the commonly used NSAIDs in cattle, including flunixin meglumine, carprofen, meloxicam, ibuprofen, aspirin, and sildenafil. Studies on the effectiveness of certain steroid drugs on the PR have also been described. The results were not always consistent, and so comparisons between studies were made. In conclusion, flunixin meglumine seems to be an option, and can be recommended for improving ET results, especially in situations of high exposure or susceptibility to stress. Its administration under all circumstances, however, might be pointless and will not lead to the desired effect.