Cargando…

Synthesis of Ribose-Coated Copper-Based Metal–Organic Framework for Enhanced Antibacterial Potential of Chloramphenicol against Multi-Drug Resistant Bacteria

The rise in bacterial resistance to currently used antibiotics is the main focus of medical researchers. Bacterial multidrug resistance (MDR) is a major threat to humans, as it is linked to greater rates of chronic disease and mortality. Hence, there is an urgent need for developing effective strate...

Descripción completa

Detalles Bibliográficos
Autores principales: Haseena, Khan, Adnan, Ghaffar, Iqra, Baty, Roua S., Abdel-Daim, Mohamed M., Habib, Shahida M., Kanwal, Tasmina, Shah, Muhammad Raza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698127/
https://www.ncbi.nlm.nih.gov/pubmed/34943681
http://dx.doi.org/10.3390/antibiotics10121469
_version_ 1784620203862130688
author Haseena,
Khan, Adnan
Ghaffar, Iqra
Baty, Roua S.
Abdel-Daim, Mohamed M.
Habib, Shahida M.
Kanwal, Tasmina
Shah, Muhammad Raza
author_facet Haseena,
Khan, Adnan
Ghaffar, Iqra
Baty, Roua S.
Abdel-Daim, Mohamed M.
Habib, Shahida M.
Kanwal, Tasmina
Shah, Muhammad Raza
author_sort Haseena,
collection PubMed
description The rise in bacterial resistance to currently used antibiotics is the main focus of medical researchers. Bacterial multidrug resistance (MDR) is a major threat to humans, as it is linked to greater rates of chronic disease and mortality. Hence, there is an urgent need for developing effective strategies to overcome the bacterial MDR. Metal–organic frameworks (MOFs) are a new class of porous crystalline materials made up of metal ions and organic ligands that can vary their pore size and structure to better encapsulate drug candidates. This study reports the synthesis of ribose-coated Cu-MOFs for enhanced bactericidal activity of chloramphenicol (CHL) against Escherichia coli (resistant and sensitive) and MDR Pseudomonas aeruginosa. The synthesized Cu-MOFs were characterized with DLS, FT-IR, powder X-ray diffraction, scanning electron microscope, and atomic force microscope. They were further investigated for their efficacy against selected bacterial strains. The synthesized ribose-coated Cu-MOFs were observed as spherical shape structure with the particle size of 562.84 ± 13.42 nm. CHL caused the increased inhibition of E. coli and MDR P. aeruginosa with significantly reduced MIC and MBIC values after being encapsulated in ribose-coated Cu-MOFs. The morphological analysis of the bacterial strains treated with ribose-coated CHL-Cu-MOFs showed the complete morphological distortion of both E. coli and MDR P. aeruginosa. Based on the results of the study, it can be suggested that ribose-coated Cu-MOFs may be an effective alternate candidate to overcome the MDR and provide new perspective for the treatment of MDR bacterial infections.
format Online
Article
Text
id pubmed-8698127
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86981272021-12-24 Synthesis of Ribose-Coated Copper-Based Metal–Organic Framework for Enhanced Antibacterial Potential of Chloramphenicol against Multi-Drug Resistant Bacteria Haseena, Khan, Adnan Ghaffar, Iqra Baty, Roua S. Abdel-Daim, Mohamed M. Habib, Shahida M. Kanwal, Tasmina Shah, Muhammad Raza Antibiotics (Basel) Article The rise in bacterial resistance to currently used antibiotics is the main focus of medical researchers. Bacterial multidrug resistance (MDR) is a major threat to humans, as it is linked to greater rates of chronic disease and mortality. Hence, there is an urgent need for developing effective strategies to overcome the bacterial MDR. Metal–organic frameworks (MOFs) are a new class of porous crystalline materials made up of metal ions and organic ligands that can vary their pore size and structure to better encapsulate drug candidates. This study reports the synthesis of ribose-coated Cu-MOFs for enhanced bactericidal activity of chloramphenicol (CHL) against Escherichia coli (resistant and sensitive) and MDR Pseudomonas aeruginosa. The synthesized Cu-MOFs were characterized with DLS, FT-IR, powder X-ray diffraction, scanning electron microscope, and atomic force microscope. They were further investigated for their efficacy against selected bacterial strains. The synthesized ribose-coated Cu-MOFs were observed as spherical shape structure with the particle size of 562.84 ± 13.42 nm. CHL caused the increased inhibition of E. coli and MDR P. aeruginosa with significantly reduced MIC and MBIC values after being encapsulated in ribose-coated Cu-MOFs. The morphological analysis of the bacterial strains treated with ribose-coated CHL-Cu-MOFs showed the complete morphological distortion of both E. coli and MDR P. aeruginosa. Based on the results of the study, it can be suggested that ribose-coated Cu-MOFs may be an effective alternate candidate to overcome the MDR and provide new perspective for the treatment of MDR bacterial infections. MDPI 2021-11-29 /pmc/articles/PMC8698127/ /pubmed/34943681 http://dx.doi.org/10.3390/antibiotics10121469 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Haseena,
Khan, Adnan
Ghaffar, Iqra
Baty, Roua S.
Abdel-Daim, Mohamed M.
Habib, Shahida M.
Kanwal, Tasmina
Shah, Muhammad Raza
Synthesis of Ribose-Coated Copper-Based Metal–Organic Framework for Enhanced Antibacterial Potential of Chloramphenicol against Multi-Drug Resistant Bacteria
title Synthesis of Ribose-Coated Copper-Based Metal–Organic Framework for Enhanced Antibacterial Potential of Chloramphenicol against Multi-Drug Resistant Bacteria
title_full Synthesis of Ribose-Coated Copper-Based Metal–Organic Framework for Enhanced Antibacterial Potential of Chloramphenicol against Multi-Drug Resistant Bacteria
title_fullStr Synthesis of Ribose-Coated Copper-Based Metal–Organic Framework for Enhanced Antibacterial Potential of Chloramphenicol against Multi-Drug Resistant Bacteria
title_full_unstemmed Synthesis of Ribose-Coated Copper-Based Metal–Organic Framework for Enhanced Antibacterial Potential of Chloramphenicol against Multi-Drug Resistant Bacteria
title_short Synthesis of Ribose-Coated Copper-Based Metal–Organic Framework for Enhanced Antibacterial Potential of Chloramphenicol against Multi-Drug Resistant Bacteria
title_sort synthesis of ribose-coated copper-based metal–organic framework for enhanced antibacterial potential of chloramphenicol against multi-drug resistant bacteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698127/
https://www.ncbi.nlm.nih.gov/pubmed/34943681
http://dx.doi.org/10.3390/antibiotics10121469
work_keys_str_mv AT haseena synthesisofribosecoatedcopperbasedmetalorganicframeworkforenhancedantibacterialpotentialofchloramphenicolagainstmultidrugresistantbacteria
AT khanadnan synthesisofribosecoatedcopperbasedmetalorganicframeworkforenhancedantibacterialpotentialofchloramphenicolagainstmultidrugresistantbacteria
AT ghaffariqra synthesisofribosecoatedcopperbasedmetalorganicframeworkforenhancedantibacterialpotentialofchloramphenicolagainstmultidrugresistantbacteria
AT batyrouas synthesisofribosecoatedcopperbasedmetalorganicframeworkforenhancedantibacterialpotentialofchloramphenicolagainstmultidrugresistantbacteria
AT abdeldaimmohamedm synthesisofribosecoatedcopperbasedmetalorganicframeworkforenhancedantibacterialpotentialofchloramphenicolagainstmultidrugresistantbacteria
AT habibshahidam synthesisofribosecoatedcopperbasedmetalorganicframeworkforenhancedantibacterialpotentialofchloramphenicolagainstmultidrugresistantbacteria
AT kanwaltasmina synthesisofribosecoatedcopperbasedmetalorganicframeworkforenhancedantibacterialpotentialofchloramphenicolagainstmultidrugresistantbacteria
AT shahmuhammadraza synthesisofribosecoatedcopperbasedmetalorganicframeworkforenhancedantibacterialpotentialofchloramphenicolagainstmultidrugresistantbacteria