Cargando…

Risk and Predictive Factors of Leptospirosis in Dogs Diagnosed with Kidney and/or Liver Disease in Selangor, Malaysia

SIMPLE SUMMARY: Canine leptospirosis is commonly associated with kidney and/or liver disease. The current study identified the potential risk and predictive factors of dogs diagnosed with kidney and/or liver disease due to leptospirosis. A total of 124 client-owned dogs were recruited and the sample...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdul Rahman, Mohammad Sabri, Khor, Kuan Hua, Khairani-Bejo, Siti, Lau, Seng Fong, Mazlan, Mazlina, Roslan, Mohd Azri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698145/
https://www.ncbi.nlm.nih.gov/pubmed/34944181
http://dx.doi.org/10.3390/ani11123405
_version_ 1784620208208478208
author Abdul Rahman, Mohammad Sabri
Khor, Kuan Hua
Khairani-Bejo, Siti
Lau, Seng Fong
Mazlan, Mazlina
Roslan, Mohd Azri
author_facet Abdul Rahman, Mohammad Sabri
Khor, Kuan Hua
Khairani-Bejo, Siti
Lau, Seng Fong
Mazlan, Mazlina
Roslan, Mohd Azri
author_sort Abdul Rahman, Mohammad Sabri
collection PubMed
description SIMPLE SUMMARY: Canine leptospirosis is commonly associated with kidney and/or liver disease. The current study identified the potential risk and predictive factors of dogs diagnosed with kidney and/or liver disease due to leptospirosis. A total of 124 client-owned dogs were recruited and the samples collected were directly tested using polymerase chain reaction (PCR) and subsequently inoculated for bacterial isolation. Statistical analyses were descriptively analyzed, and risk analyses were performed using Pearson chi-square tests and logistic regression. The different breeds of dog with history of exposure to rats and those managed outdoors had a greater risk of leptospirosis (p < 0.05). The significant predictors for the dogs’ positivity were presence of rats and acute clinical illness (p < 0.05). Administration of antibiotics and detection of clinical illness at an early stage of the disease improved the survivability of the dogs (p < 0.05). ABSTRACT: Canine leptospirosis is commonly associated with kidney and/or liver disease. It has been widely reported and causes public health concerns due to its zoonotic potential and its re-emergence, resulting from close contact between humans and dogs. The current study identified potential risk and predictive factors for dogs diagnosed with kidney and/or liver disease due to leptospirosis. A total of 124 client-owned dogs were recruited, and information such as signalment, medical history, management, and clinical findings were documented. Samples collected from the recruited dogs were directly tested using polymerase chain reaction (PCR) and subsequently inoculated for bacterial isolation. Statistical analyses were descriptively analyzed, and risk analyses were performed using Pearson chi-square tests and logistic regression. A total of 53 dogs (42.7%) were positive for leptospiral infection based on PCR, and 10 leptospiral isolates were successfully recovered from eight dogs. The mortality rate of infected dogs was 34.0% (18/53). Medium and large dog breeds, with a history of exposure to rats, and managed outdoors had a greater risk for leptospirosis (p < 0.05). The significant predictors for the dogs’ positivity were the presence of rats and acute clinical illness (p < 0.05). Administration of antibiotics and the detection of clinical illness at an early stage of the disease improved the survivability of the dogs (p < 0.05). Identifying the profile of dogs that are at risk to leptospirosis could be useful in the design of diagnostic and treatment strategies, as well as to increase awareness for prevention of the disease.
format Online
Article
Text
id pubmed-8698145
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86981452021-12-24 Risk and Predictive Factors of Leptospirosis in Dogs Diagnosed with Kidney and/or Liver Disease in Selangor, Malaysia Abdul Rahman, Mohammad Sabri Khor, Kuan Hua Khairani-Bejo, Siti Lau, Seng Fong Mazlan, Mazlina Roslan, Mohd Azri Animals (Basel) Article SIMPLE SUMMARY: Canine leptospirosis is commonly associated with kidney and/or liver disease. The current study identified the potential risk and predictive factors of dogs diagnosed with kidney and/or liver disease due to leptospirosis. A total of 124 client-owned dogs were recruited and the samples collected were directly tested using polymerase chain reaction (PCR) and subsequently inoculated for bacterial isolation. Statistical analyses were descriptively analyzed, and risk analyses were performed using Pearson chi-square tests and logistic regression. The different breeds of dog with history of exposure to rats and those managed outdoors had a greater risk of leptospirosis (p < 0.05). The significant predictors for the dogs’ positivity were presence of rats and acute clinical illness (p < 0.05). Administration of antibiotics and detection of clinical illness at an early stage of the disease improved the survivability of the dogs (p < 0.05). ABSTRACT: Canine leptospirosis is commonly associated with kidney and/or liver disease. It has been widely reported and causes public health concerns due to its zoonotic potential and its re-emergence, resulting from close contact between humans and dogs. The current study identified potential risk and predictive factors for dogs diagnosed with kidney and/or liver disease due to leptospirosis. A total of 124 client-owned dogs were recruited, and information such as signalment, medical history, management, and clinical findings were documented. Samples collected from the recruited dogs were directly tested using polymerase chain reaction (PCR) and subsequently inoculated for bacterial isolation. Statistical analyses were descriptively analyzed, and risk analyses were performed using Pearson chi-square tests and logistic regression. A total of 53 dogs (42.7%) were positive for leptospiral infection based on PCR, and 10 leptospiral isolates were successfully recovered from eight dogs. The mortality rate of infected dogs was 34.0% (18/53). Medium and large dog breeds, with a history of exposure to rats, and managed outdoors had a greater risk for leptospirosis (p < 0.05). The significant predictors for the dogs’ positivity were the presence of rats and acute clinical illness (p < 0.05). Administration of antibiotics and the detection of clinical illness at an early stage of the disease improved the survivability of the dogs (p < 0.05). Identifying the profile of dogs that are at risk to leptospirosis could be useful in the design of diagnostic and treatment strategies, as well as to increase awareness for prevention of the disease. MDPI 2021-11-29 /pmc/articles/PMC8698145/ /pubmed/34944181 http://dx.doi.org/10.3390/ani11123405 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abdul Rahman, Mohammad Sabri
Khor, Kuan Hua
Khairani-Bejo, Siti
Lau, Seng Fong
Mazlan, Mazlina
Roslan, Mohd Azri
Risk and Predictive Factors of Leptospirosis in Dogs Diagnosed with Kidney and/or Liver Disease in Selangor, Malaysia
title Risk and Predictive Factors of Leptospirosis in Dogs Diagnosed with Kidney and/or Liver Disease in Selangor, Malaysia
title_full Risk and Predictive Factors of Leptospirosis in Dogs Diagnosed with Kidney and/or Liver Disease in Selangor, Malaysia
title_fullStr Risk and Predictive Factors of Leptospirosis in Dogs Diagnosed with Kidney and/or Liver Disease in Selangor, Malaysia
title_full_unstemmed Risk and Predictive Factors of Leptospirosis in Dogs Diagnosed with Kidney and/or Liver Disease in Selangor, Malaysia
title_short Risk and Predictive Factors of Leptospirosis in Dogs Diagnosed with Kidney and/or Liver Disease in Selangor, Malaysia
title_sort risk and predictive factors of leptospirosis in dogs diagnosed with kidney and/or liver disease in selangor, malaysia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698145/
https://www.ncbi.nlm.nih.gov/pubmed/34944181
http://dx.doi.org/10.3390/ani11123405
work_keys_str_mv AT abdulrahmanmohammadsabri riskandpredictivefactorsofleptospirosisindogsdiagnosedwithkidneyandorliverdiseaseinselangormalaysia
AT khorkuanhua riskandpredictivefactorsofleptospirosisindogsdiagnosedwithkidneyandorliverdiseaseinselangormalaysia
AT khairanibejositi riskandpredictivefactorsofleptospirosisindogsdiagnosedwithkidneyandorliverdiseaseinselangormalaysia
AT lausengfong riskandpredictivefactorsofleptospirosisindogsdiagnosedwithkidneyandorliverdiseaseinselangormalaysia
AT mazlanmazlina riskandpredictivefactorsofleptospirosisindogsdiagnosedwithkidneyandorliverdiseaseinselangormalaysia
AT roslanmohdazri riskandpredictivefactorsofleptospirosisindogsdiagnosedwithkidneyandorliverdiseaseinselangormalaysia