The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD

SIMPLE SUMMARY: Dioxins are proinflammatory factors that may be transferred to offspring through the placenta during pregnancy. α-tocopherol and acetylsalicylic acid are popular agents that limit the spread of inflammation. A histopathological and biochemical analysis was performed to reveal possible changes in liver and blood plasma in response to dioxins, α-tocopherol, and acetylsalicylic acid. The conducted research demonstrated the presence of negative effects on the liver morphology and blood plasma proteins of offspring, due to dioxins that were derived from the mother. However, the use of both drugs can significantly reduce the negative effects on offspring whose mothers have been treated with dioxins. ABSTRACT: Dioxins are chemical compounds that may cause an inflammatory reaction. During dioxin-induced inflammation, generated reactive oxygen species lead to morphological changes in various tissues and in biochemical parameters. The aim of this study was to demonstrate the changes in the livers of rats whose mothers were exposed to dioxins and the protective role of α-tocopherol and acetylsalicylic acid in liver inflammation. The study material consisted of Buffalo rats who were the offspring of females treated with dioxin, dioxin + α-tocopherol, or dioxin + acetylsalicylic acid. Livers and blood samples were taken from the rats’ offspring, and then histopathological and biochemical analyses were performed. The histopathological analysis showed that the changes observed in the livers of neonates were the result of the dioxins derived from their mother. The biochemical analysis showed that the morphological changes in the liver affected its function, which manifested in a higher total protein concentration in the dioxin-treated group, and that the creatinine level in this group was significantly higher than that in the other groups. This effect was reduced by the protective role of α-tocopherol and acetylsalicylic acid. Based on these results, we came to the conclusion that dioxins significantly affect the structure of the liver, which negatively affects its function, mainly in the scope of the metabolism of plasma proteins and hepatic enzymes.