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The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs

SIMPLE SUMMARY: The vast majority of pet food products on the market contain the major mineral phosphorus in amounts exceeding the recommended daily allowance. A considerable amount of phosphorus in such products is highly water-soluble and bioavailable. Even though a sufficient supply of phosphorus...

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Autores principales: Dobenecker, Britta, Kienzle, Ellen, Siedler, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698167/
https://www.ncbi.nlm.nih.gov/pubmed/34944233
http://dx.doi.org/10.3390/ani11123456
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author Dobenecker, Britta
Kienzle, Ellen
Siedler, Stephanie
author_facet Dobenecker, Britta
Kienzle, Ellen
Siedler, Stephanie
author_sort Dobenecker, Britta
collection PubMed
description SIMPLE SUMMARY: The vast majority of pet food products on the market contain the major mineral phosphorus in amounts exceeding the recommended daily allowance. A considerable amount of phosphorus in such products is highly water-soluble and bioavailable. Even though a sufficient supply of phosphorus is important for the body, an excessive intake can be harmful, especially in renal patients but also healthy individuals. This study investigated the effects of an excessive intake of organic phosphate sources (e.g., meat and bone meal) and inorganic phosphate salts compared with a balanced control diet without inorganic phosphates on factors of the body’s phosphorus regulatory system in healthy, adult beagle dogs. Most inorganic phosphates but not the organic phosphorus sources caused significant changes in these regulatory factors compared with the control diet. We conclude that the use of these inorganic phosphates in pet food is potentially harmful and should be restricted. ABSTRACT: Elevated serum phosphate concentrations are an established risk factor for cardiovascular disease and mortality in chronic kidney disease in various species. Independent associations of other parameters of phosphorus metabolism, such as phosphorus intake from different sources and serum concentrations of phosphorus, as well as parameters involved in the regulation, such as parathyroid hormone (PTH) or markers of bone turnover, have been studied in less detail. Therefore, the serum kinetics of phosphate, PTH, and the bone resorption marker bone-specific alkaline phosphatase (BAP) were investigated after 18 days of feeding a control diet and diets supplemented with eight different organic and inorganic phosphate sources aiming at 1.8% phosphorus per dry matter and calcium to phosphorus ratio between 1.3 and 1.7 to 1. Eight healthy beagle dogs (f/m, 2–4 years, 12.9 ± 1.4 kg body weight) were available for the trial. Highly significant differences in the serum kinetics of phosphorus, PTH, and BAP with the highest postprandial levels after feeding highly water-soluble sodium and potassium phosphates were found. We conclude that the use of certain inorganic phosphates in pet food is potentially harmful and should be restricted.
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spelling pubmed-86981672021-12-24 The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs Dobenecker, Britta Kienzle, Ellen Siedler, Stephanie Animals (Basel) Article SIMPLE SUMMARY: The vast majority of pet food products on the market contain the major mineral phosphorus in amounts exceeding the recommended daily allowance. A considerable amount of phosphorus in such products is highly water-soluble and bioavailable. Even though a sufficient supply of phosphorus is important for the body, an excessive intake can be harmful, especially in renal patients but also healthy individuals. This study investigated the effects of an excessive intake of organic phosphate sources (e.g., meat and bone meal) and inorganic phosphate salts compared with a balanced control diet without inorganic phosphates on factors of the body’s phosphorus regulatory system in healthy, adult beagle dogs. Most inorganic phosphates but not the organic phosphorus sources caused significant changes in these regulatory factors compared with the control diet. We conclude that the use of these inorganic phosphates in pet food is potentially harmful and should be restricted. ABSTRACT: Elevated serum phosphate concentrations are an established risk factor for cardiovascular disease and mortality in chronic kidney disease in various species. Independent associations of other parameters of phosphorus metabolism, such as phosphorus intake from different sources and serum concentrations of phosphorus, as well as parameters involved in the regulation, such as parathyroid hormone (PTH) or markers of bone turnover, have been studied in less detail. Therefore, the serum kinetics of phosphate, PTH, and the bone resorption marker bone-specific alkaline phosphatase (BAP) were investigated after 18 days of feeding a control diet and diets supplemented with eight different organic and inorganic phosphate sources aiming at 1.8% phosphorus per dry matter and calcium to phosphorus ratio between 1.3 and 1.7 to 1. Eight healthy beagle dogs (f/m, 2–4 years, 12.9 ± 1.4 kg body weight) were available for the trial. Highly significant differences in the serum kinetics of phosphorus, PTH, and BAP with the highest postprandial levels after feeding highly water-soluble sodium and potassium phosphates were found. We conclude that the use of certain inorganic phosphates in pet food is potentially harmful and should be restricted. MDPI 2021-12-04 /pmc/articles/PMC8698167/ /pubmed/34944233 http://dx.doi.org/10.3390/ani11123456 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dobenecker, Britta
Kienzle, Ellen
Siedler, Stephanie
The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs
title The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs
title_full The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs
title_fullStr The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs
title_full_unstemmed The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs
title_short The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs
title_sort source matters–effects of high phosphate intake from eight different sources in dogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698167/
https://www.ncbi.nlm.nih.gov/pubmed/34944233
http://dx.doi.org/10.3390/ani11123456
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